Results 171 to 180 of about 66,099 (245)

A toolkit for mapping cell identities in relation to neighbors reveals conserved patterning of neuromesodermal progenitor populations. [PDF]

PLoS Biol
French M, Migueles RP, Neaverson A, Chakraborty A, Pettini T, Steventon B, Clark E, Dale JK, Blin G, Wilson V, Lowell S.   +10 more
europepmc   +1 more source

The fast‐dissociating D2 antagonist antipsychotic JNJ‐37822681 is a neuronal Kv7 channel opener: Potential repurposing for epilepsy treatment

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Pharmacological activation of neuronal M‐current mediated by Kv7 (Kv7.2–5) potassium channels is a validated mechanism for epilepsy treatment. However, since the market withdrawal of the prototype Kv7 activator retigabine, no Kv7 activator is clinically available for this condition.
Lidia Carotenuto, Oliver Keminer, Giusy Carleo, Andrea Zaliani, Antonio Leo, Rita Citraro, Giovambattista De Sarro, Nina Dirkx, Marcus Kaji, Sarah Weckhuysen, Jeanette Reinshagen, Vincenzo Barrese, Natascia Guida, Carmine Ostacolo, Francesco Miceli, Philip Gribbon, Maurizio Taglialatela   +16 more
wiley   +1 more source

Sox5 controls the establishment of quiescence in neural stem cells during postnatal development. [PDF]

PLoS Biol
Medina-Menéndez C, Tirado-Melendro P, Li L, Rodríguez-Martín P, Melgarejo-de la Peña E, Díaz-García M, Valdés-Bescós M, López-Sansegundo R, Morales AV.   +8 more
europepmc   +1 more source

Activation of pluripotency-associated genes in mouse embryonic fibroblasts by non-viral transfection with in vitro-derived mRNAs encoding Oct4, Sox2, Klf4 and cMyc [PDF]

, 2011
Geertrui Tavernier, Katharina Wolfrum, Joseph Demeester, Stefaan C. De Smedt, James Adjaye, Joanna Rejman   +5 more
openalex   +1 more source

Epithelial–Mesenchymal Transition and Genetically Driven Early Tumor Seedings in Extraneural Metastasis of Glioblastoma

Cancer Science, EarlyView.
Genetic and cell biological analyses of this rare glioblastoma (GBM) case with rapidly progressive pleural metastasis revealed essential roles of epithelial‐mesenchymal transition (EMT) and glioma stem‐like cells (GSCs) in extraneural metastasis. Contrary to the common prediction, analyses of the primary, recurrent, and metastatic tumors indicated that
Seisaku Kanayama, Kentaro Watanabe, Minoru Tanaka, Junko Takita, Tomoki Todo   +4 more
wiley   +1 more source

Isolated hypogonadotropic hypogonadism with SOX2 mutation and anophthalmia/microphthalmia in offspring [PDF]

, 2011
Zornitza Stark, Rebecca Storen, Bruce Bennetts, Ravi Savarirayan, Robyn V. Jamieson   +4 more
openalex   +1 more source

Implication of GPRASP2 in the Proliferation and Hair Cell‐Forming of Cochlear Supporting Cells

Cell Proliferation, EarlyView.
Schematic diagram of GPRASP2‐mediated SCs proliferation and HCs formation. GPRASP2 deficiency results in increased lysosomal degradation of SMO. GPRASP2‐mediated SMO/GLI1 signalling promotes SC proliferation, which contributes to HC formation. GPRASP2‐mediated SMO/β‐catenin signalling is implicated in HCs fate specification and differentiation ...
Jing Cai, Kun Huang, Wenrui Li, Tianming Wang, Shen Yue, Zhibin Chen, Guangqian Xing, Qinjun Wei, Jun Yao, Xin Cao   +9 more
wiley   +1 more source

OCT3-4 and SOX2 in Oral Lichen Planus Compared to Oral Leukoplakia: An Immunohistochemical Study. [PDF]

Cureus
Zisis V, Giannakopoulos NN, Poulopoulos A, Schmitter M, Andreadis D.   +4 more
europepmc   +1 more source

Hypertranscription of rDNA Responsible for Nucleolar Remodelling is a Doorman for Acquiring Pluripotency

Cell Proliferation, EarlyView.
Active nucleoli have the capability to release perinuclear heterochromatin, which is a novel event of iPSC reprogramming. ABSTRACT Ribosome biogenesis occurs within the nucleolus, with the initial step being the transcription of ribosomal DNA (rDNA). Although rDNA transcription is limited in somatic cells, it is more active in stem cells. Nevertheless,
Yuchen Sun, Xinglin Hu, Xingwei Huang, Wenyao Zhou, Shubing Lan, Hui Zhang, Guangming Wu, Lei Lei   +7 more
wiley   +1 more source

Unlocking the Role of OCT4 in Cancer Lineage Plasticity: A Cross-Cancer Perspective with an Emphasis on Prostate Cancer. [PDF]

Biomedicines
Esfini Farahani M, Zhang Y, Akinyemi AO, Seilani F, Alam MR, Liu X.   +5 more
europepmc   +1 more source