Results 181 to 190 of about 70,586 (295)

Data from MCAM Mediates Chemoresistance in Small-Cell Lung Cancer via the PI3K/AKT/SOX2 Signaling Pathway

, 2023
S. C. Tripathi, Johannes F. Fahrmann, Müge Çeliktaş, Mitzi Aguilar, Kieren D. Marini, Mohit Kumar Jolly, Hiroyuki Katayama, Hong Wang, Eunice Murage, Jennifer B. Dennison, D. Neil Watkins, Herbert Levine, Edwin J. Ostrin, Ayumu Taguchi, Samir Hanash   +14 more
openalex   +1 more source

Dysregulation of Rho‐Associated Coiled‐Coil Protein Kinase1 Depletes Neural Stem Cell Pool and Impairs Hippocampal Neurogenesis After Traumatic Brain Injury

Cell Proliferation, EarlyView.
Following TBI, hippocampal neurogenesis in mice is impaired and affects cognitive function. This impairment is associated with the upregulation of p‐AKT/AKT mediated by ROCK1. ABSTRACT Traumatic brain injury (TBI) represents a global health burden, often resulting in persistent neurological deficits due to impaired hippocampal neurogenesis ...
Chaoqun Yao, Long Jin, Jun Zhong, Qianying Huang, Zhongwei Bao, Shaolong Zhou, Chaohua Wang, Huanhuan Li, Xiaowei Yuan, Zhen Wang, Ning Du, Jingxuan Yu, Huanran Chen, Xuyang Zhang, Hongfei Ge, Jianheng Wu   +15 more
wiley   +1 more source

Clinicopathological Significance of Pluripotent Factors in Sinonasal Intestinal-Type Adenocarcinoma. [PDF]

Cancers (Basel)
Monaco F, Vallieri A, Volpini L, Foschini MP, Filosa A, Antolini E, Gioacchini FM, Sollini G, Pasquini E, Iannella G, Neuzil J, Amati M, Santarelli L, Tomasetti M, Re M.   +14 more
europepmc   +1 more source

Evolutionary Analysis of Transcriptional Regulation Mediated by Cdx2 in Rodents

Cell Proliferation, EarlyView.
Our study (1) represented a first systematic analysis of species‐specific adaptation in the DNA binding pattern of transcription factor; (2) represented a first study of cis‐regulation between two reproductively isolated species by using a novel allodiploid system; (3) demonstrated a higher conservation of transcriptional output than that of DNA ...
Weizheng Liang, Guipeng Li, Yukai Wang, Wencheng Wei, Rui Chen, Siyue Sun, Diwen Gan, Hongyang Yi, Bernhard Schaefke, Yuhui Hu, Qi Zhou, Wei Li, Huanhuan Cui, Wei Chen   +13 more
wiley   +1 more source

Neurogenesis decreases in the offspring of mothers infected with influenza A virus. [PDF]

Front Cell Infect Microbiol
Rakovskaya A, Lozhkov A, Zabrodskaya Y, Kirenskaya V, Korovina O, Garshinina A, Zryacheva V, Shtro A, Pchitskaya E, Vlasova O, Elpaeva E, Moshkoff D, Salvato M, Bezprozvanny I, Vasin A.   +14 more
europepmc   +1 more source

Cancer-driven IgG promotes the development of castration-resistant Prostate Cancer though the SOX2-CIgG pathway [PDF]

, 2020
Caipeng Qin, Zhengzuo Sheng, Xinmei Huang, Jingshu Tang, Yang Liu, Tao Xu, Xiaoyan Qiu   +6 more
openalex   +1 more source

Transcription Factor TCF12‐Mediated Maternal Gene Expressions in Mouse Oocyte Are Prerequisites of Successful Fertilisation and Zygotic Genome Activation

Cell Proliferation, EarlyView.
Maternal TCF12 ensures the competence of fertilisation by controlling the expression of Astl and the proper location of cortical granules. Furthermore, maternal TCF12 maintains the phosphatase activity of PP2A by regulating the expression of Arpp19. Oocyte‐specific deletion of Tcf12 leads to fertilisation defects as well as ZGA failure at the 2‐cell ...
Lan‐Rui Cao, Chi Zhang, Zuo‐Qi Deng, Yue‐xin Qiu, Zhao Zhang, Heng‐Yu Fan, Jing Li, Hong‐Bo Wu   +7 more
wiley   +1 more source

Evaluation of the prognostic role of SOX2 as a tumor stem cell marker in odontogenic cysts and tumors: clinical, radiographic and immunohistochemical correlation. [PDF]

BMC Oral Health
Zeen El-Abdeen HM, Tawfik MA, Elnagdy SY, Mansour NA.   +3 more
europepmc   +1 more source

Development of NAFLD‐Specific Human Liver Organoid Models on a Microengineered Array Chip for Semaglutide Efficacy Evaluation

Cell Proliferation, EarlyView.
Microporous array organ chips were integrated with commercially available well plates to develop organoid chip platforms, which enable modelling of hepatic physiology and non‐alcoholic fatty liver disease (NAFLD) pathogenesis, as well as evaluation of semaglutide therapeutics. ABSTRACT Progressive non‐alcoholic fatty liver disease (NAFLD) may culminate
Xiao‐yan You, Xiang‐yang Li, Hui Wang, Guo‐ping Zhao   +3 more
wiley   +1 more source

SOX2/SOX17 Molecular Switching by Polyphenols to Promote Thyroid Differentiation in 2D and 3D Models of Anaplastic Thyroid Cancer ^†. [PDF]

Biology (Basel)
Vaglica F, Biondo M, Siragusa G, Arnaldi G, Guarnotta V, Pizzolanti G, Tomasello L.   +6 more
europepmc   +1 more source