Results 61 to 70 of about 12,256,776 (281)
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
A policy guide for depositing journal articles as open access at the School of Advanced Study [PDF]
An interactive diagram showing the process for checking requirements and uploading a newly accepted journal article to SAS ...
SAS Space Manager
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Combinatorial Space Tiling [PDF]
, 2010 The present article studies combinatorial tilings of Euclidean or spherical spaces by polytopes, serving two main purposes: first, to survey some of the main developments in combinatorial space tiling; and second, to highlight some new and some old open ...
Schulte, Egon
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Test Spaces for Normal Spaces [PDF]
Proceedings of the American Mathematical Society, 1962 Let Q be a class of topological spaces. For X in Q, let dim X denote the dimension of X defined in terms of finite open coverings. If Q is the class of all normal spaces, then the dimension of spaces X in Q is characterized by the following theorem [2, p. 212]: dimX^n if, and only if, given any closed subset C of X, any continuous mapping of C into the
openaire +2 more sources
Molecular Oncology, EarlyView.A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He +8 more
wiley +1 more source
, 2008 This booklet includes 31 problems that involve a variety of math skills, including scientific notation, simple algebra, and calculus. Topics covered include black holes, ice on mercury, a mathematical model of the solar interior, sunspots, the heliopause,
Sten Odenwald
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Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
, 2019 I wrote this piece for myself as a hybrid of personal discovery and academic inquiry, and I hope it can guide and empower others like myself. In this piece, I examine the intersections of queer identity with religious and spiritual identity development ...
Long, Patrick Griffin
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