Results 61 to 70 of about 13,348,458 (329)
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
The space of intervals in a Euclidean space
, 2005 For a path-connected space X, a well-known theorem of Segal, May and Milgram asserts that the configuration space of finite points in R^n with labels in X is weakly homotopy equivalent to the n-th loop-suspension of X. In this paper, we introduce a space
May +3 more
core +1 more source
FEBS Letters, EarlyView.At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom +3 more
wiley +1 more source
A policy guide for depositing journal articles as open access at the School of Advanced Study [PDF]
An interactive diagram showing the process for checking requirements and uploading a newly accepted journal article to SAS ...
SAS Space Manager
core
Advanced dosimetry systems for the space transport and space station [PDF]
, 1972 Advanced dosimetry system concepts are described that will provide automated and instantaneous measurement of dose and particle spectra. Systems are proposed for measuring dose rate from cosmic radiation background to greater than 3600 rads/hr.
Clark, B. C. +2 more
core +1 more source
Test Spaces for Normal Spaces [PDF]
Proceedings of the American Mathematical Society, 1962 Let Q be a class of topological spaces. For X in Q, let dim X denote the dimension of X defined in terms of finite open coverings. If Q is the class of all normal spaces, then the dimension of spaces X in Q is characterized by the following theorem [2, p. 212]: dimX^n if, and only if, given any closed subset C of X, any continuous mapping of C into the
openaire +2 more sources
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source
Interpreting Craig for new audiences [PDF]
, 2010 Kate Bailey, Curator of Space and Light: Edward Gordon Craig, will introduce the exhibition and discuss the interpretation of the subject, the creative process and the engagement of new and international audiences with Craig's work. Scriptwriter Jane
Bailey, Kate, Collins, Jane
core
Quark helicity distributions in transverse momentum space and transverse coordinate space
, 2013 The transverse momentum dependent helicity distributions of valence quarks are calculated in the light-cone diquark model by adopting two different approaches.
Lu, Zhun, Ma, Bo-Qiang
core +1 more source