Results 91 to 100 of about 4,099,821 (310)

Clinical utility of cerebrospinal fluid biomarkers measured by LUMIPULSE® system

Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1898-1909, December 2022., 2022
Abstract Objectives Cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD) are well‐established in research settings, but their use in routine clinical practice remains a largely unexploited potential. Here, we examined the relationship between CSF biomarkers, measured by a fully automated immunoassay platform, and brain β‐amyloid (Aβ ...
Hisashi Nojima, Satoshi Ito, Akira Kushida, Aki Abe, Wataru Motsuchi, David Verbel, Manu Vandijck, Geert Jannes, Ina Vandenbroucke, Katsumi Aoyagi   +9 more
wiley   +1 more source

The Role of Magnetic Skeleton in Solar Flare Filaments Activity

The Astrophysical Journal
We report an M9.3 flare and filaments activities from NOAA Active Region 11261 that are strongly modulated by the 3D magnetic skeleton. Magnetic field extrapolation from the vector magnetic field suggests complex magnetic connectivity and the existence ...
Juan Guo, Huaning Wang, Jingxiu Wang, Xiaoshuai Zhu, Jing Huang, Shanqiang Chen, Bingxian Luo, Siqing Liu, Yuanyong Deng, Jiaben Lin   +9 more
doaj   +1 more source

EU Space Doctrine – Sustainable Development or a New Arms Race [PDF]

Advanced Space Law
Strategic documents of the European Union (EU) in the space sphere are analyzed in this Article. It is concluded that despite the active use of the “space doctrine” concept in the EU, regulating public legal relations through the establishment and ...
Larysa Soroka, Anna Danylenko
doaj   +1 more source

The principle of the space activity suit [PDF]

Space activity suit designed for active astronaut working in vacuum environments for up to four ...
Annis, J. F., Webb, P.
core   +1 more source

Physical activity and spatial use during school break times in children aged four [PDF]

, 2017
Poster de CongresoAnalyze quantity of physical activity and use of space during school break times according to gender, in four-year-old pupils.Universidad de Málaga.
Fernández-Rodríguez, Emilio, Gonzalez Campos, Gloria, Merino-Marban, Rafael, Romero-Ramos, Oscar   +3 more
core  

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Vascular endothelial‐cadherin as a marker of endothelial injury in preclinical Alzheimer disease

Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1926-1940, December 2022., 2022
Abstract Objective Endothelial dysfunction is an early and prevalent pathology in Alzheimer disease (AD). We here investigate the value of vascular endothelial‐cadherin (VEC) as a cerebrospinal fluid (CSF) marker of endothelial injury in preclinical AD.
Rawan Tarawneh, Rachel S. Kasper, Jessie Sanford, Chia‐Ling Phuah, Jason Hassenstab, Carlos Cruchaga   +5 more
wiley   +1 more source

Cool Stars and Space Weather

, 2014
Stellar flares, winds and coronal mass ejections form the space weather. They are signatures of the magnetic activity of cool stars and, since activity varies with age, mass and rotation, the space weather that extra-solar planets experience can be very ...
Alvarado, J., Cameron, A. C., Cohen, O., Holzwarth, V., Jardine, M., Morin, J., Poppenhaeger, K., Reville, V., Saar, S., Vidotto, A. A., Villadsen, J.   +10 more
core  

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

The clinical spectrum of SMA‐PME and in vitro normalization of its cellular ceramide profile

Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1941-1952, December 2022., 2022
Abstract Objective The objectives of this study were to define the clinical and biochemical spectrum of spinal muscular atrophy with progressive myoclonic epilepsy (SMA‐PME) and to determine if aberrant cellular ceramide accumulation could be normalized by enzyme replacement.
Michelle M. Lee, Graeme S. V. McDowell, Darryl C. De Vivo, Daniel Friedman, Samuel F. Berkovic, Maria Spanou, Argirios Dinopoulos, Katheryn Grand, Pedro A. Sanchez‐Lara, Michelle Allen‐Sharpley, Jodi Warman‐Chardon, Alexander Solyom, Thierry Levade, Edward H. Schuchman, Steffany A. L. Bennett, David A. Dyment, Toni S. Pearson   +16 more
wiley   +1 more source