Results 121 to 130 of about 4,099,821 (310)

Evaluation of synaptotagmin‐1 action models by all‐atom molecular dynamics simulations

open access: yesFEBS Open Bio, EarlyView.
We used molecular dynamics simulations to test models proposing that synaptotagmin‐1 facilitates membrane fusion by perturbing lipid bilayers, inducing membrane curvature and/or bridging membranes. The simulations show that synaptotagmin‐1 C2‐domains placed near the site of fusion hinder the ability of SNARE complexes to bring the membranes together ...
Josep Rizo   +2 more
wiley   +1 more source

Multi-scale energy release events in the quiet Sun: a possible source for coronal heating

open access: yesFrontiers in Astronomy and Space Sciences
The coronal heating problem remains one of the most challenging questions in solar physics. The energy driving coronal heating is widely understood to be associated with convective motions below the photosphere. Recent high-resolution observations reveal
Rui Wang   +5 more
doaj   +1 more source

Spacecraft architecture [PDF]

open access: yes
Three requirements for a spacecraft interior are considered. Adequate motor activity in the anatomical-physiological sense results from attention to the anthropometric characteristics of humans.
Zefeld, V. V.
core   +1 more source

Situating Kant’s Pre-Critical Monadology: Leibnizian Ubeity, Monadic Activity, and Idealist Unity [PDF]

open access: yes, 2016
This essay examines the relationship between monads and space in Kant’s early pre-critical work, with special attention devoted to the question of ubeity, a Scholastic doctrine that Leibniz describes as “ways of being somewhere”. By focusing attention on
Slowik, Edward
core  

FAM136A depletion induces mitochondrial stress and reduces mitochondrial membrane potential and ATP production

open access: yesFEBS Open Bio, EarlyView.
FAM136A depletion upregulated ROS production, reduced mitochondrial membrane potential (ΔΨ) and ATP production, and upregulated expression of PCK1, PCK2, HMGCS1, and HMGCS2. The expression of both TOMM22 and TOMM20 was also upregulated. FAM136A depletion reduced HCCS that produce holocytochrome c by combining heme to apocytochrome c, and reduced the ...
Yushi Otsuka, Masato Yano
wiley   +1 more source

Technology Teacher: Listening for Rings from Space [PDF]

open access: yes, 2004
This activity introduces gravitational waves and the NASA technology being developed to detect them in space. It involves building a metaphorical interferometer that demonstrates how the mission (and all interferometry) works.
NASA JPL
core  

Activity statistics in a colloidal glass former: experimental evidence for a dynamical transition

open access: yes, 2017
In a dense colloidal suspension at a volume fraction slightly lower than that of its glass transition, we follow the trajectories of an assembly of tracers over a large time window.
Abou, Bérengère   +4 more
core   +2 more sources

Pharmacological effects of osimertinib on a chicken chorioallantoic membrane xenograft model with the EGFR exon‐19‐deleted advanced NSCLC mutation

open access: yesFEBS Open Bio, EarlyView.
Osimertinib reduces angiogenesis and PDL1 expression in in ovo tumors, transforming them into ‘cold tumors’ with lower immune activity. Anatomopathological and transcriptomic analyses highlight its therapeutic impact on tumor biology. This study underscores osimertinib's potential to reshape the tumor microenvironment and provides insights into its ...
David Barthélémy   +14 more
wiley   +1 more source

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