Results 71 to 80 of about 986,496 (318)
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Martian Ionospheric Cold Hydrogen Ion Escape at Solar Maximum: First Observations
The Astrophysical JournalThe water escape from Mars to space could be in the form of hydrogen and oxygen ions as driven by solar wind–Mars interactions. Although oxygen ion escape has been extensively investigated, the H ^+ escape rate was measured only at solar minimum.
Qi Xu +10 more
doaj +1 more source
UniverseThe precise monitoring of solar flares holds significant scientific value for space mission safety, communication security, and space environment forecasting.
Hongyan Li +3 more
doaj +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
A Physics-informed Deep Learning Model for the Magnetic Classification of Solar Active Regions
The Astrophysical Journal Supplement SeriesSolar active regions (ARs) are the source of solar eruptive events such as flares. The morphology of sunspots within ARs is closely related to solar eruptive activity.
Ming Li +5 more
doaj +1 more source
Impact of lower atmospheric scattering on ground-based optical thermospheric wind observations with spatially uneven airglow [PDF]
Atmospheric Measurement TechniquesScattered airglow emissions in the lower atmosphere can bias ground-based interferometer observations of thermospheric winds, particularly when airglow brightness becomes spatially uneven due to auroras. During two geomagnetic storms with visible auroras
X. Wei +19 more
doaj +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Operational Solar Flare Ensemble Forecasting Model for Full-disk Active Regions
The Astrophysical Journal Supplement SeriesSolar flares are explosive releases of magnetic energy in localized regions of the solar atmosphere that threaten the safety of solar–terrestrial technological systems, making their forecasting critical for space-weather-forecasting support services ...
Ming Li +5 more
doaj +1 more source
Continuous space representations of human activity spaces
, 2005 Arbeitsberichte Verkehrs- und Raumplanung ...
Vaze, Vikrant S. +2 more
openaire +2 more sources
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source