Results 81 to 90 of about 3,656,515 (237)
Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer
Molecular Oncology, EarlyView.Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte +10 more
wiley +1 more source
The space station: Human factors and productivity [PDF]
Human factor researchers and engineers are making inputs into the early stages of the design of the Space Station to improve both the quality of life and work on-orbit.
Burns, M. J. +3 more
core +1 more source
Molecular Oncology, EarlyView.In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton +17 more
wiley +1 more source
A Time-Space Analysis of Urban Activities with Focus on the Relationship between ICT and Activity-Travel [PDF]
Information and communications technology (ICT) has evolved substantially and impacted urban residents’ everyday life quite substantially in the past decade.
Katsunao Kondo +3 more
core
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
On the wings of a dream: The Space Shuttle [PDF]
Described are the organization and some of the interests and missions of NASA, the Space Transportation System, the Space Shuttle orbiter Enterprise, astronaut training and clothing, being launched into space, living and working in weightlessness ...
core +1 more source
SOLAR ERUPTION ON 4 JANUARY 2011: CASE STUDY FOR SPACE EARLY WARNING [PDF]
, 2011 We perform intuitive analysis for solar eruption on 4 January 2011. Since we do not have magnetic observational data from the eruption, we perform first order calculation and expands it as interplanetary total effect of energy propagation by retro ...
Bambang, Setiahadi
core
Understanding and measuring mechanical signals in the tumor stroma
FEBS Open Bio, EarlyView.This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz +3 more
wiley +1 more source
The intravehicular activity space suit Final report, 5 Aug. 1968 - 1 Feb. 1970 [PDF]
Design and testing of intravehicular activity space ...
Friedman, D.
core +1 more source