Results 51 to 60 of about 1,666,454 (346)

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Simulation and Validation of Real-Time UAV-Based GNSS-R Altimetry Across Diverse Landforms

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
Accurate measurement of land surface elevation is essential for applications, such as terrain mapping, environmental monitoring, and ecological assessment.
Ziyin Xu, Xianyi Wang, Junming Xia, Zhenhe Zhai, Zhuoyan Wang, Cheng Liu, Yusen Tian, Tongsheng Qiu, Yueqiang Sun, Qifei Du, Weihua Bai, Feixiong Huang, Cong Yin   +12 more
doaj   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Particle track imaging simulation and expected outcomes of the Grid-based energetic neutral atom imager (GENA) for the Queqiao-2 mission

Earth, Planets and Space
The two-dimensional Grid-based Energetic Neutral Atom (GENA) imager, carried by the Queqiao-2 relay communication satellite, utilizes two narrow side-by-side multi-pixel shared collimators. In this study, a new set of response functions was developed for
Li Lu, Qing-long Yu, Jin-fa Shao, Yuan Chang, Zhong Xie, Jian Lan, Shuai Jia   +6 more
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Unraveling the Role of Electron Plateau Distributions in the Power Gap Formation of Chorus Waves: Van Allen Probes Observations

Geophysical Research Letters, 2023
The power gap of chorus waves at ∼0.5fce has been discovered for decades, but its generation mechanism is still under debate. Previous studies have revealed that electron plateau distributions are vitally important for the gap formation.
Huayue Chen, Rui Chen, Xinliang Gao, Quanming Lu, Yangguang Ke, Zhenyu Kong   +5 more
doaj   +1 more source

Symbiotic CPS Design-Space Exploration through Iterated Optimization [PDF]

, 2023
Sheng-Jung Yu, Inigo Incer, Valmik Prabhu, Anwesha Chattoraj, Eric Vin, Daniel J. Fremont, Ankur Mehta, Alberto Sangiovanni‐Vincentelli, S. Shankar Sastry, Sanjit A. Seshia   +9 more
openalex   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Estimation of Mode Transition in a Supersonic Combustor

Journal of Thermal Science and Technology, 2013
A quasi-one dimensional calculation was carried out to figure out supersonic combustor performances. Three flow tubes were considered in the combustor region. Those were an air-flow-tube, a combustion-flow-tube and a fuel-flow-tube.
Junji NODA, Atsuo MURAKAMI, Kenji KUDO, Sadatake TOMIOKA   +3 more
doaj   +1 more source