Results 91 to 100 of about 4,948,216 (289)
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Slug Test in a Large Dip Angle Fracture Zone: Model and Field Experiment
Terrestrial, Atmospheric and Oceanic Sciences, 2015 A single-porosity model is developed to deal with a fracture zone slug test in a large dip angle by assuming the fracture zone causes a downward regional flow.
Ying Liu and Chia-Shyun Chen
doaj +1 more source
The Needle is Moving in CA K-8 Science: Integration with ELA, Integration of the Sciences, and Returning Science as a K-8 Core Subject [PDF]
, 2016 This first EII evaluation publication discusses one of the major shifts above, namely the shift to integrated instruction. The integration of science and ELA is the focus of one section, and the integration of the science disciplines (i.e., earth/space ...
Ashley Iveland +4 more
core
Molecular Oncology, EarlyView.A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He +8 more
wiley +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Abundant Landslides Associated with Extreme Weather Change During the 2009 Typhoon Morakot
Terrestrial, Atmospheric and Oceanic Sciences, 2015 The abundance of landslides that occurred in Taiwan in August of 2009 is not only attributed to extremely heavy rainfall but also extreme weather change from a dry period that occurred one month before the landslides to extremely heavy rainfall within a ...
Cheng-Horng Lin
doaj +1 more source
Science objectives of the "Millimetron" Space Observatory and its technical implementation
, 2020 I. D. Novikov +20 more
openalex +1 more source
Geometry from Information Geometry
, 2015 We use the method of maximum entropy to model physical space as a curved statistical manifold. It is then natural to use information geometry to explain the geometry of space.
Caticha, Ariel
core +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source