Results 91 to 100 of about 31,547,886 (300)

Structural and biochemical analysis of a B12 superbinder

open access: yesFEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices   +3 more
wiley   +1 more source

Living Inside the UA Space Analog

open access: yes
Immediate accessThis item is made available by the University of Arizona Center for Human Space Exploration (CHaSE) with support from the University of Arizona Libraries.
Tresch, Trent
core   +4 more sources

Earth's Atmospheric Electricity Parameter Response During Venus Transit

open access: yesTerrestrial, Atmospheric and Oceanic Sciences, 2015
Venus transited across the Sun on 06 June 2012, introducing significant contribution to the tidal characteristics of the solar atmosphere. _ atmosphere was perturbed due to an anomalous Coronal Mass Ejection (CME) and γ-radiationγ-radiation influenced by
Syam Sundar De   +4 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

open access: yesFEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav   +2 more
wiley   +1 more source

Virus Effect on Marine Synechococcus Spp. Loss in Subtropical Western Pacific Coastal Waters During Winter

open access: yesTerrestrial, Atmospheric and Oceanic Sciences, 2015
Little is known about microbial processes and the effect that viruses have on Synechococcus spp. in aquatic environments. This study investigated diel variations in the Synechococcus spp. abundance in three size-fractionated water samples (200, 10, and 2
An-Yi Tsai   +2 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Slug Test in a Large Dip Angle Fracture Zone: Model and Field Experiment

open access: yesTerrestrial, Atmospheric and Oceanic Sciences, 2015
A single-porosity model is developed to deal with a fracture zone slug test in a large dip angle by assuming the fracture zone causes a downward regional flow.
Ying Liu and Chia-Shyun Chen
doaj   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

open access: yesFEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui   +4 more
wiley   +1 more source

Prospecting the protein design landscape

open access: yesFEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona   +4 more
wiley   +1 more source

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