FEBS Letters, EarlyView.This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao +7 more
wiley +1 more source
Can Space Tourism Boost Sustainable Behavior?
Frontiers in Psychology, 2021 Nicola Mammarella
doaj +1 more source
Investigating Near Surface S-Wave Velocity Properties Using Ambient Noise in Southwestern Taiwan
Terrestrial, Atmospheric and Oceanic Sciences, 2015 Ambient noise is typically used to estimate seismic site effects and velocity profiles instead of earthquake recordings, especially in areas with limited seismic data.
Chun-Hsiang Kuo +4 more
doaj +1 more source
Space Math: Solar Storms and You! Exploring Satellite Design [PDF]
, 2000 This educator’s guide includes activities in space science.
Sten Odenwald
core
Science in the Elementary and Middle School: Earth and Space Science Starting Points [PDF]
This chapter focuses on students' alternative conceptions of science that create a barrier to learning concepts in Earth and space science. Using specific examples of basic content and concepts addressing elementary and middle school, a strategy for ...
Bishop +33 more
core +1 more source
Single‐cell insights into the role of T cells in B‐cell malignancies
FEBS Letters, EarlyView.Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley +1 more source
Space station science lab module [PDF]
The Science Lab Module (SLM), a key component of the proposed Space Station (SS) orbiting complex, is undergoing intensive study during the project design phase which is currently underway.
Devincenzi, D. L.
core +1 more source
TRAF2 binds to TIFA via a novel motif and contributes to its autophagic degradation
FEBS Letters, EarlyView.TRAF family members couple receptor signalling complexes to downstream outputs, but how they interact with these complexes is not always clear. Here, we show that during ADP‐heptose signalling, TRAF2 binding to TIFA requires two short sequence motifs in the C‐terminal tail of TIFA, which are distinct from the TRAF6 binding motif.
Tom Snelling +4 more
wiley +1 more source
The rocks from space “Space Safari”: an example of remote public engagement in the planetary sciences [PDF]
, 2010 We describe an integrated online science programme incorporating Moodle virtual learning environments (VLEs) and Elluminate Live! virtual classrooms. The “Space Safari” was run as part of the Rocks From Space (RFS) programme hosted at The Open University
Brooks, Val, Pearson, Victoria
core
Planetary Radio Interferometry and Doppler Experiment (PRIDE) Technique: a Test Case of the Mars Express Phobos Fly-by. 2. Doppler tracking: Formulation of observed and computed values, and noise budget [PDF]
, 2017 Context. Closed-loop Doppler data obtained by deep space tracking networks (e.g., NASA's DSN and ESA's Estrack) are routinely used for navigation and science applications.
Bocanegra-Bahamón, T. M. +7 more
core +3 more sources