Results 81 to 90 of about 5,668,523 (337)
The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1
FEBS Letters, EarlyView.MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson +7 more
wiley +1 more source
Regional Flooding Induced by Tide and Warm Water Effects in Tuvalu
Terrestrial, Atmospheric and Oceanic Sciences, 2015 A statistical model for simulating flood inundation in Tuvalu is developed in this study. The model is based on the major regional inundation factors - spring tides and warm-water mass, integrated with the digital elevation.
Chen-Chih Lin +3 more
doaj +1 more source
The China Space Station: a new opportunity for space science. [PDF]
Natl Sci Rev, 2022 Gu Y.
europepmc +1 more source
FEBS Letters, EarlyView.Tuberculosis remains a global health challenge and new therapeutic targets are required. Here, we characterized SseA, a sulfurtransferase from Mycobacterium tuberculosis involved in macrophage infection, and its interaction with the newly identified protein SufEMtb that activates SseA enzymatic activity.
Giulia Di Napoli +10 more
wiley +1 more source
Daris, a low-frequency distributed aperture array for radio astronomy in space [PDF]
, 2010 DARIS (Distributed Aperture Array for Radio Astronomy in Space) is a radio astronomy space mission concept aimed at observing the low-frequency radio sky in the range 1-10 MHz.
Bentum, M.J. +4 more
core +1 more source
FEBS Letters, EarlyView.This work presents the characterization of MvoDUF2193, a Methanococcus voltae (Mvo) protein from the domain of unknown function (DUF) 2193 family. We demonstrate that MvoDUF2193 binds a single [4Fe–4S] cluster per subunit and that cluster occupancy regulates the transition from an apo tetramer to a [4Fe–4S] monomeric form. This structural transition is
Emily M. Dieter +8 more
wiley +1 more source
An Ensemble Algorithm Based Component for Geomagnetic Data Assimilation
Terrestrial, Atmospheric and Oceanic Sciences, 2015 Geomagnetic data assimilation is one of the most recent developments in geomagnetic studies. It combines geodynamo model outputs and surface geomagnetic observations to provide more accurate estimates of the core dynamic state and provide accurate ...
Zhibin Sun and Weijia Kuang
doaj +1 more source
Space science & the space economy
Will it be possible in the future to realize large, complex space missions dedicated to basic science like HST, Chandra and JWST? Or will their cost be just too great? Today's space scene is completely different from that of even five years ago, and certainly from that of the time when HST, Chandra and JWST were conceived and built.
Fiore, F., Elvis, M.
openaire +2 more sources
Neutrophil deficiency increases T cell numbers at the site of tissue injury in mice
FEBS Letters, EarlyView.In wild‐type mice, injury or acute inflammation induces neutrophil influx followed by macrophage accumulation. Mcl1ΔMyelo (neutrophil‐deficient) mice lack neutrophils, and in response to muscle injury show fewer macrophages and exhibit strikingly elevated T‐cell numbers, primarily non‐conventional “double‐negative” (DN) αβ and γδ T cells.
Hajnalka Halász +6 more
wiley +1 more source