Results 81 to 90 of about 4,948,216 (289)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Broadening Access to Space Science Data: The Astromaterials Data System [PDF]

, 2020
Jennifer Mays, Lucia Profeta, Kerstin Lehnert, Peng Ji, Shaunna M. Morrison, Annika Johansson, Lulin Song, Juan David Figueroa, Cindy Evans, R. A. Zeigler   +9 more
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Earth's Atmospheric Electricity Parameter Response During Venus Transit

Terrestrial, Atmospheric and Oceanic Sciences, 2015
Venus transited across the Sun on 06 June 2012, introducing significant contribution to the tidal characteristics of the solar atmosphere. _ atmosphere was perturbed due to an anomalous Coronal Mass Ejection (CME) and γ-radiationγ-radiation influenced by
Syam Sundar De, Suman Paul, Sudarsan Barui, Dilip Kumar Haldar, and Gautam Guha   +4 more
doaj   +1 more source

Recoverable satellites and space science experiments in China [PDF]

, 2009
Chunhua Li, Runli Ni
openalex   +1 more source

Introducing the New Editor in Chief of <em>Earth and Space Science</em>

, 2022
Graziella Caprarelli
openalex   +1 more source

Research in space science [PDF]

Baker-Nunn photography of Syncom II fourth stage ignition and Centaur vehicle AC-

core   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Virus Effect on Marine Synechococcus Spp. Loss in Subtropical Western Pacific Coastal Waters During Winter

Terrestrial, Atmospheric and Oceanic Sciences, 2015
Little is known about microbial processes and the effect that viruses have on Synechococcus spp. in aquatic environments. This study investigated diel variations in the Synechococcus spp. abundance in three size-fractionated water samples (200, 10, and 2
An-Yi Tsai, Gwo-Ching Gong, and Shu Ling Hu   +2 more
doaj   +1 more source