Results 71 to 80 of about 51,680 (312)

Endogenous “Time Bomb” – Mislocalized Phospholipase A2 as a Critical Mediator of Ultra‐Rapid Mortality in Sepsis and Acute Lung Injury

Advanced Science, EarlyView.
Phospholipase A2 (PLA2), a dormant enzyme, becomes lethal when activated—collapsing lungs in minutes. Our dual therapy (DOPS + varespladib) boosts survival from 0% to >90% in sepsis/ALI. A breakthrough for acute lung injury treatment. ABSTRACT This study reveals that phospholipase A2 (PLA2), normally stable and nontoxic, can be activated specifically ...
Jianyu Wang, Zhongxing Xu, Lin Wang, Xin Sui, Yuan Luo, Xiuli Zhao, Jun Yang, Yongan Wang   +7 more
wiley   +1 more source

Spark Ignition Measurements in Jet A: part II [PDF]

, 2000
An improved system for measuring the ignition energy of liquid fuel was built to perform experiments on aviation kerosene (Jet A). Compared to a previously used system (Shepherd et al. 1998), the present vessel has a more uniform temperature which can be
Lee, Julian J., Shepherd, Joseph E.
core  

Characterisation of Flame Development with Hydrous and Anhydrous Ethanol Fuels in a Spark-Ignition Engine with Direct Injection and Port Injection Systems [PDF]

, 2014
This paper presents a study of the combustion mechanism of hydrous and anhydrous ethanol in comparison to iso-octane and gasoline fuels in a single-cylinder spark-ignition research engine operated at 1000 rpm with 0.5 bar intake plenum pressure.
Aleiferis, PG, Augoye, AK
core   +1 more source

An Artificial Antibody‐Based Toolbox Accelerates Validation of Hidden Microproteins Encoded by the Dark Genome

Advanced Science, EarlyView.
Microproteins are hidden treasures encoded by the “dark proteome” but remain largely underexplored due to the lack of highly efficient tools. We developed a molecularly imprinted polymers (MIPs)‐based toolbox (CLAIMID) to achieve accelerated and ultrasensitive microproteins validation at multiple biological scales (single living cells, cell populations,
Hui He, Anqi Zhang, Zhanchen Guo, Qi Li, Song Gao, Wenyan Guan, Ying Li, Jingran Chen, Sijia Sun, Jian He, Zhen Liu   +10 more
wiley   +1 more source

Stochastic stability for a model representing the intake manifold pressure of an automotive engine [PDF]

, 2016
The paper presents conditions to assure stochastic stability for a nonlinear model. The proposed model is used to represent the input-output dynamics of the angle of aperture of the throttle valve (input) and the manifold absolute pressure (output) in an
Acho Zuppa, Leonardo, Arens, Walter, Bonifacio, Edison, do Val, Joao B. R., Nascimiento, Alessandro Vargas do   +4 more
core   +2 more sources

Localized NF‐κB Inhibition Reduces Lipid Nanoparticle‐Associated Inflammation

Advanced Science, EarlyView.
Lipid nanoparticles (LNPs) activate NF‐κB and provoke inflammation that limits therapeutic delivery. By encapsulating selective NF‐κB inhibitors within LNPs, localized suppression of inflammatory signaling is achieved without compromising mRNA expression.
Carolann L. Espy, Jichuan Wu, Serena Omo‐Lamai, Liuqian Wang, Fengyi Dong, Aleksa Milosavljevic, Sarah O'Neill, Taylor Brysgel, Yufei Wang, Michael Zaleski, Emily Wolfe, Rhea Maheshwari, Manthan Patel, Dirk Trauner, Jia Nong, Zhicheng Wang, Jacob S. Brenner   +16 more
wiley   +1 more source

Experimental investigation of dual fuel (gasoline-natural gas) in lean burn ICE

International Journal of Thermofluids
Investigating the performance and emission indices of spark ignition engines in our society is a critical issue. This importance arises from the high performance requirements and the need to achieve the highest level of efficiency from existing spark ...
Seyyed Kazem Yekani, Mehrdad Sarabi, Mahdi Nami Khalilehdeh   +2 more
doaj   +1 more source

Transition region ignition characteristics of n-heptane fuel sprays [PDF]

Ignition studies were perferred on monodisperse n-heptane sprays at atmospheric pressure over a range of equivalence ratios and droplet diameters. A capacitive discharge spark ignition system was used as the ignition source, providing independent control
Cernansky, N. P., Danis, A. M., Namer, I.   +2 more
core   +1 more source

Hydrogen SI and HCCI Combustion in a Direct-Injection Optical Engine [PDF]

, 2009
Hydrogen has been largely proposed as a possible alternative fuel for internal combustion engines. Its wide flammability range allows higher engine efficiency with leaner operation than conventional fuels, for both reduced toxic emissions and no CO2 ...
Aleiferis, PG, Rosati, MF
core   +1 more source

Delivery of Pleckstrin‐Homology Domains Suppresses PI3K/Akt Signaling and Breast Cancer Metastasis

Advanced Science, EarlyView.
Current therapies curb tumor growth but not metastasis. Obscurin, a giant metastasis suppressor lost in breast cancer, restrains PI3K/Akt signaling but is impractical to restore. We deploy a mini‐obscurin, comprising the obscurin‐PH‐domain, which sequesters PI3K‐p85, potently suppressing invasion and metastasis.
Matthew Eason, Anindya Sen, Suhan Cho, Se Jong Lee, Keyata Thompson, Md Musavvir Mahmud, Poornima Dubey, Talia Guardia, Anthony Kim, Stuart Martin, Nathan Wright, Konstantinos Konstantopoulos, Aikaterini Kontrogianni‐Konstantopoulos   +12 more
wiley   +1 more source