Results 71 to 80 of about 29,371 (197)

Mutation analysis of the spastin gene (SPG4) in patients with hereditary spastic paraparesis

Background-Hereditary spastic paraparesis is a genetically heterogeneous condition. Recently, mutations in the spastin gene were reported in families Linked to the common SPG4 locus on chromosome 2p21-22. Objectives-To study a population of patients with
Rubinsztein DC, Hazan J, Shaw PJ, Lindsey JC, Bushby KMD, McDermott CJ, White KD, Bashir R, Reid E, Lusher ME   +9 more
core   +5 more sources

Molecular Evidence of Human T‑Cell Leukemia Virus Type 1 Transmission by Needlestick Injury in Healthcare Workers

Journal of Medical Virology, Volume 98, Issue 9, September 2026.
ABSTRACT Human T‑cell leukemia virus type 1 (HTLV‑1) is a retrovirus that spreads primarily through cell‐to‐cell transmission. Occupational transmission of HTLV‐1 by needlestick injury is considered exceedingly rare, with no reported molecularly confirmed cases.
Masahito Tokunaga, Madoka Kuramitsu, Masumichi Saito, Miyuki Yoshimori, Jun Odawara, Yoshikiyo Ito, Hitomi Nakamura, Yasuko Sagara, Mieko Ishii, Naomi Nojiri, Hazuka Yoshida‐Furihata, Wakako Kuribayashi, Takuo Mizukami, Kiyonori Miura, Atae Utsunomiya   +14 more
wiley   +1 more source

FXTAS and the Spectrum of FMR1 Premutation‐Associated Phenotypes in Latin America: A Scoping Review

Movement Disorders Clinical Practice, Volume 13, Issue 9, Page 2045-2058, September 2026.
Abstract Background Fragile X–associated tremor/ataxia syndrome (FXTAS) is a late‐onset neurodegenerative disorder caused by FMR1 premutation expansions (55–200 CGG repeats). Although well described in populations of predominantly European ancestry, FXTAS remains poorly characterized in Latin America due to limited awareness, restricted access to ...
Amy Schmidmajer, Salomón Páez‐García, Santiago Martínez, Jacobo Ramírez‐Triana, Kevin O'Hara‐Veintimilla, Andrés Ricaurte‐Fajardo, Catalina Cerquera‐Cleves   +6 more
wiley   +1 more source

Brain atrophy in pure and complicated hereditary spastic paraparesis: a quantitative 3D MRI study

, 2006
Hereditary spastic paraparesis (HSP) is a heterogeneous group of neurodegenerative disorders with progressive lower limb spasticity, categorized into pure (p-HSP) and complicated forms (c-HSP).
Kassubek, J, Juengling, F D, Baumgartner, A, Riecker, A, Huppertz, H-J, Sperfeld, A-D   +5 more
core   +1 more source

Phenotypic Exploration in Patients with Heterozygous Variant in AFG3L2 Gene: A Case‐Series and Literature Review

Movement Disorders Clinical Practice, Volume 13, Issue 9, Page 2250-2258, September 2026.
Abstract Background Variants in AFG3‐Like Matrix AAA Peptidase, Subunit 2 (AFG3L2) gene are associated with diverse clinical phenotypes. Here, we describe phenotypic findings of two unrelated children with de novo heterozygous variant and one family with inherited heterozygous variant in AFG3L2 gene.
Sangeetha Yoganathan, Laura Tochen, Jacky Ganguly, Sayoni Roy Chowdhury, Haya S AlFaris, Vivek Pai, Andrea LeBlanc‐Millar, Sara Breitbart, Hrishikesh Kumar, Manohar Shroff, Arun Reginald, Grace Yoon, Alfonso Fasano, George M Ibrahim, Carolina Gorodetsky   +14 more
wiley   +1 more source

Brain and spinal cord magnetic resonance imaging in spastic paraparesis associated to human T-lymphotropic virus [PDF]

, 2006
Background: The spastic paraparesis associated to HTLV-1 causes degenerative pyramidal tract lesions of the spinal cord and affects cortical-nuclear connections in the brain.
García F., Luis, Cartier Rovirosa, Luis, Cervilla O., Jorge   +2 more
core  

Epilepsia secundária a neurocisticercose: número de calcificações x tipos de crises [PDF]

, 2001
Trabalho de Conclusão de Curso - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Departamento de Clínica Médica, Curso de Medicina, Florianópolis ...
Newton, Fábio Antunes
core  

Fluorosis Masquerading as Compressive Myelopathy

National Board of Examinations Journal of Medical Sciences
A 60-year-old woman from Cuddalore presented with restricted neck movements, progressive difficulty in walking, and lower limb weakness, leading to bed confinement.
Jayaram Saibaba, Gopinath Karuppiah
doaj   +1 more source

Caracterização molecular do HTLV-1 em pacientes com paraparesia espástica tropical/mielopatia associada ao HTLV-1 em Belém, Pará Molecular characterization of HTLV-1 among patients with tropical spastic paraparesis/HTLV-1 associated myelopathy in Belém, Pará

Revista da Sociedade Brasileira de Medicina Tropical, 2006
O presente estudo avaliou a ocorrência da infecção pelo HTLV-1 e seus subtipos em amostras de sangue de pacientes com diagnóstico clínico de paraparesia espástica tropical/mielopatia associada ao Htlv-1.
Lucinda A. Souza, Ivina G.L. Lopes, Eduardo Leitão Maia, Vânia N. Azevedo, Luiz Fernando A. Machado, Marluísa O.G. Ishak, Ricardo Ishak, Antonio Carlos R. Vallinoto   +7 more
doaj   +1 more source

Using the International Classification of Functioning, Disability and Health as a tool for analysis of the effect of physical therapy on spasticity in HAM/TSP patients

Revista da Sociedade Brasileira de Medicina Tropical, 2015
INTRODUCTION: This study aimed to evaluate spasticity in human T-lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients before and after physical therapy using the International Classification of Functioning ...
Luana Rego Rodrigues, Luzielma Macedo Glória, Mayara do Socorro Brito dos Santos, Rita Medeiros, George Alberto da Silva Dias, Denise da Silva Pinto   +5 more
doaj   +1 more source