Results 71 to 80 of about 453,054 (303)
ISPRS International Journal of Geo-Information, 2022 In order to access the spatial accessibility of emergency shelters, the relationship between the supply and demand of emergency shelters in the two dimensions of space and non-space must be comprehensively considered. Meanwhile, it is vital to understand
Zilin Ding +5 more
doaj +1 more source
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
A Random Multiple-Access Protocol with Spatial Interactions [PDF]
Journal of Applied Probability, 2007 We analyse an ALOHA-type random multiple-access protocol where users have local interactions. We show that the fluid model of the system workload satisfies a certain differential equation. We obtain a sufficient condition for the stability of this differential equation and deduce from that a sufficient condition for the stability of the protocol.
Bordenave, C., Foss, S.G., Shneer, V.
openaire +7 more sources
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
A multi-modal relative spatial access assessment approach to measure spatial accessibility to primary care providers [PDF]
International Journal of Health Geographics, 2018 Two-step floating catchment area (2SFCA) methods that account for multiple transportation modes provide more realistic accessibility representation than single-mode methods. However, the use of the impedance coefficient in an impedance function (e.g., Gaussian function) introduces uncertainty to 2SFCA results.
Yan Lin +4 more
openaire +3 more sources
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Choice and the composition of general practice patient registers [PDF]
, 2009 Choice of general practice (GP) in the National Health Service (NHS), the UKs universal healthcare service, is a core element in the current trajectory of NHS policy. This paper uses an accessibility-based approach to investigate the pattern of patient
Lewis, D., Longley, P., Mateos, P.
core
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Spatially Modulated Code-Division Multiple-Access for High-Connectivity Multiple Access [PDF]
IEEE Transactions on Wireless Communications, 2019 In order to take the advantages of spatial modulation (SM) and support the multiple-access (MA) communications requiring high connectivity, we integrate the SM with DS-CDMA to propose a SM/DS-CDMA scheme, which is in favor of attaining both antenna diversity and frequency diversity. Associated with the SM/DS-CDMA scheme, a range of linear and nonlinear
Peng Pan, Lie-Liang Yang
openaire +3 more sources