Results 81 to 90 of about 453,054 (303)
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Geospatial HealthEquitable spatial accessibility to vaccination sites is essential for enhancing the effectiveness of infectious disease prevention and control. While traffic modes significantly influence the evaluation of spatial accessibility to vaccination sites ...
Wentao Yang +5 more
doaj +1 more source
External productivity and utility effects of city airports [PDF]
, 2011 This paper uses a micro-level data set for residential and commercial property transactions to investigate external utility and productivity effects for three (city) airports in Berlin, Germany in a spatial hedonic analysis.
Ahlfeldt, Gabriel M., Maennig, Wolfgang
core +3 more sources
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
Agglomeration, accessibility and industrial location: evidence from spanish municipalities [PDF]
This paper deals with the location decisions of manufacturing firms in Spain. We analyse how agglomeration economies and transport accessibility influence the location decisions of firms at municipality level and in three industries.
Josep-Maria Arauzo-Carod +1 more
core
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
MODELING SPATIAL ACCESSIBILITY WITHIN DISCRETE CHOICE FRAMEWORK [PDF]
Spatial accessibility is concerned with the opportunity that an individual at a given location possesses to participate in a particular activity or set of activities.
Guo, Xiaoqi, Ulimwengu, John M.
core +1 more source
The role of public transport in addressing sustainable mobility for the elderly population in Malta [PDF]
, 2013 Over the past few years, several countries have continued experiencing a growth in their elderly population. Similarly, a number of towns and villages in Malta registered a high elderly population in the last census (NSO, 2012).
Attard, Maria, Mifsud, Deborah
core +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source