The newfound relationship between extrachromosomal DNAs and excised signal circles
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Assessing spatial heterogeneity patterns along human footprint (HF) gradients is important for understanding biodiversity conservation in human-modified landscapes.
Kyoung-Ho Kim +6 more
doaj +1 more source
Spatial preference heterogeneity in forest recreation [PDF]
Heterogeneity in household preferences for recreational use of forests may lead to spatial sorting, i.e., households choose their residential location in accordance with their preference for forest recreation. In this study, we analyze the preferences for recreational use of forests in Lorraine (Northeastern France), applying stated preference data ...
Abildtrup, Jens +3 more
openaire +6 more sources
Spatial heterogeneity and irreversible vegetation change in semi-arid grazing systems [PDF]
Recent theoretical studies have shown that spatial redistribution of surface water may explain the occurrence of patterns of alternating vegetated and degraded patches in semiarid grasslands.
Andel, J., van +11 more
core +2 more sources
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Effects of stream grazers with different functional traits on the spatial heterogeneity of periphyton mats [PDF]
Background Grazing activity on periphytic mats determines mat structure and spatial heterogeneity. Spatial complexity in stream periphyton is highly divergent and may depend on the functional traits of the different primary consumers species (i.e ...
Izumi Katano, Hideyuki Doi
doaj +2 more sources
Spatial heterogeneity promotes coexistence of rock-paper-scissor metacommunities
The rock-paper-scissor game -- which is characterized by three strategies R,P,S, satisfying the non-transitive relations S excludes P, P excludes R, and R excludes S -- serves as a simple prototype for studying more complex non-transitive systems.
Allesina +66 more
core +1 more source
Modeling Transport Mode Decisions Using Hierarchical Binary Spatial Regression Models with Cluster Effects [PDF]
This work is motivated by a mobility study conducted in the city of Munich, Germany. The variable of interest is a binary response, which indicates whether public transport has been utilized or not.
Czado, Claudia, Prokopenko, S.
core +2 more sources
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source
Soil Spatial Heterogeneity and Systems of Agriculture
Aim. To consider soil continuality and discreteness as features of heterogeneity manifestation in a soil cover, important for construction of agriculture systems. Methods. Geostatistical research of soil spatial heterogeneity, revealing the contours of a
V. Medvedev
doaj +1 more source

