Results 81 to 90 of about 3,984,310 (349)

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Encapsulating Spatially Varying Relationships with a Generalized Additive Model

ISPRS International Journal of Geo-Information
This paper describes the use of Generalized Additive Models (GAMs) to create regression models whose coefficient estimates vary with geographic location—spatially varying coefficient (SVC) models. The approach uses Gaussian Process (GP) splines (smooths)
Alexis Comber, Paul Harris, Daisuke Murakami, Tomoki Nakaya, Narumasa Tsutsumida, Takahiro Yoshida, Chris Brunsdon   +6 more
doaj   +1 more source

Spatial Heterogeneity, Broadband, and New Firm Formation

Kvalita Inovácia Prosperita, 2017
Purpose: This paper examines the spatial heterogeneity associated with broadband Internet and new firm formation in a number of U.S. states. Methodology/Approach: Both ordinary least-squares regression and Geographically Weighted Regression are used ...
Jitendra Parajuli, Kingsley Haynes
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

A multiple spatial scales water use simulation for capturing its spatial heterogeneity through cellular automata model [PDF]

Hydrology and Earth System Sciences
Reliable water use simulation is essential for sustainable water resource planning, especially under intensifying pressures from climate change, population growth, and socio-economic transitions.
J. Zhang, D. Liu, D. Liu, D. Liu, J. Wang, F. Yue, H. Liang, Z. Peng, W. Guan   +8 more
doaj   +1 more source

Mathematical Modelling of Mosquito Dispersal in a Heterogeneous Environment. [PDF]

, 2012
Mosquito dispersal is a key behavioural factor that affects the persistence and resurgence of several vector-borne diseases. Spatial heterogeneity of mosquito resources, such as hosts and breeding sites, affects mosquito dispersal behaviour and ...
Alonso, Angelina Mageni Lutambi, Arino, Arino, Bayoh, Beier, Blower, Britch, Britch, Cano, Cariboni, Chitnis, Chitnis, Clarke, Cummins, Depinay, Gething, Gu, Hay, Hoare, Jeefoo, Jin, Keeling, Killeen, Kirby, Knols, Le Menach, Le Menach, Li, Li, Manga, Martens, Meinsma, Melissa A. Penny, Midega, Minakawa, Mwandawiro, Nakul Chitnis, Ngwa, Nourridine, Okogun, Otero, Otero, O’Sullivan, Raffy, Saul, Service, Service, Smallegange, Smith, Smith, Stoddard, Takken, Tatem, Thomas Smith, Tran, van den Driessche, Vazquez-Prokopec, White, Yakob, Yaro   +60 more
core   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Quantifying the spatial heterogeneity of geographical flows

Geo-spatial Information Science
Geographical flows describe the movements and connections of materials, energy, and information among locations and are commonly represented by origin-destination (OD) flows (flows for short).
Hua Shu, Tao Pei, Ci Song, Sihui Guo, Jie Chen, Yaxi Liu, Xi Wang, Xiao Chen, Chenghu Zhou   +8 more
doaj   +1 more source

Determination of intertidal macroalgae community patterns using the power law model.

PLoS ONE, 2022
The spatial heterogeneity of macroalgae in intertidal zones affects the stability of marine ecosystem communities, contributes to the maintenance of coastal biodiversity, and has an essential role in ecosystem and habitat maintenance.
Xunmeng Li, Jianqu Chen, Jun Li, Kai Wang, Zhenhua Wang, Shouyu Zhang   +5 more
doaj   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source