14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa +2 more
wiley +1 more source
It is contended that space can act as a metaphor for social relationships. The thesis draws on schema theory from cognitive psychology to explain how the affective qualities of social stimuli serve to bias the 'cognitive maps' of individuals ...
MacBride, S. J. C.
core
Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková +3 more
wiley +1 more source
Skill-testing chemical transport models across contrasting atmospheric mixing states using radon-222
We propose a new technique to prepare statistically-robust benchmarking data for evaluating chemical transport model meteorology and air quality parameters within the urban boundary layer.
Hiep Duc (20234835) +13 more
core
Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source
Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee +6 more
wiley +1 more source
Processing speed deficits: A missing link in understanding individual variation in children's interval timing skills? [PDF]
Parr MNDN +7 more
europepmc +1 more source
The Spatial Distribution of Human Capital: Can It Really Be Explained by Regional Differences in Market Access? [PDF]
This paper tests the robustness of estimates of market access impact on regional variability in human capital, as previously derived in the NEG literature.
Enrique López-Bazo +1 more
core
Why human connection is the true metric of research success
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan +3 more
wiley +1 more source
Bidirectional Relations Between Spatial and Mathematics Skills in Elementary School Children: The Role of Domain-Specific Anxieties. [PDF]
Geer EA, Barroso C, Ganley CM.
europepmc +1 more source

