Results 261 to 270 of about 71,340 (293)

Spatial transcriptomics and the kidney

Current Opinion in Nephrology & Hypertension, 2022
Purpose of review The application of spatial transcriptomics technologies to the interrogation of kidney tissue is a burgeoning effort. These technologies share a common purpose in mapping both the expression of individual molecules and entire transcriptomic signatures of kidney cell types and structures.
Melo Ferreira, Ricardo, Gisch, Debora L., Eadon, Michael T.   +2 more
openaire   +2 more sources

Spatial Transcriptomics in Kidney Tissue

2023
Unlike bulk and single-cell/single-nuclei RNA sequencing methods, spatial transcriptome sequencing (ST-seq) resolves transcriptome expression within the spatial context of intact tissue. This is achieved by integrating histology with RNA sequencing. These methodologies are completed sequentially on the same tissue section placed on a glass slide with ...
Raghubar, Arti M., Crawford, Joanna, Jones, Kahli, Lam, Pui Y., Andersen, Stacey B., Matigian, Nicholas A., Ng, Monica S.Y., Healy, Helen, Kassianos, Andrew J., Mallett, Andrew J.   +9 more
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Spatially resolved transcriptomics in neuroscience

Nature Methods, 2021
One major challenge in neuroscience is to gain a systematic understanding of the extraordinary diversity of brain cell types and how they contribute to brain function. Spatially resolved transcriptomics holds unmatched promise in unraveling the organization of brain cell types and their relationship with connectivity, circuit dynamics, behavior and ...
Jennie L. Close, Brian R. Long, Hongkui Zeng   +2 more
openaire   +2 more sources

Spatial Transcriptomics Arena (STAr): an Integrated Platform for Spatial Transcriptomics Methodology Research

2023
AbstractThe emerging field of spatially resolved transcriptomics (SRT) has revolutionized biomedical research. SRT quantifies expression levels at different spatial locations, providing a new and powerful tool to interrogate novel biological insights.
Xi, Jiang, Danni, Luo, Esteban, Fern Ndez, Jie, Yang, Huimin, Li, Kevin W, Jin, Yuanchun, Zhan, Bo, Yao, Suhana, Bedi, Guanghua, Xiao, Xiaowei, Zhan, Qiwei, Li, Yang, Xie   +12 more
openaire   +2 more sources

Spatial transcriptomics in glomerular diseases

Rheumatology
Abstract Spatial transcriptomics enables the study of the mechanisms of disease through gene expression and pathway activity analysis in a spatial context. Originally mainly employed in oncology, the techniques developed use different methods of transcript identification, resolution (single cells vs regions), flexibility of target ...
Renate Kain, André Oszwald
openaire   +2 more sources

Spatial transcriptomic applications in orthopedics

Connective Tissue Research
This review highlights the transformative impact of spatial transcriptomics on orthopedic research, focusing on its application in deciphering intricate gene expression patterns within musculoskeletal tissues.The paper reviews literature for spatial transcriptomic methods, specifically 10X Visium, 10X Xenium, seqFISH+, MERFISH, NanoString GeoMx DSP ...
Thomas L. Jenkins, Jasper H.N. Yik, Dominik R. Haudenschild   +2 more
openaire   +2 more sources

Spatial transcriptomics

2023
Dheeraj Chandra Joshi, Surendra Singh Patel, Beena Pillai   +2 more
openaire   +1 more source

Single-cell spatial transcriptomics

Nature Cell Biology, 2021
openaire   +2 more sources

Integrating single-cell and spatial transcriptomics to elucidate intercellular tissue dynamics

Nature Reviews Genetics, 2021
Sophia K Longo, Margaret G Guo, Andrew L Ji   +2 more
exaly  

Exploring tissue architecture using spatial transcriptomics

Nature, 2021
Anjali Rao, Dalia Barkley, Itai Yanai
exaly