Results 201 to 210 of about 3,488 (219)
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SmartGate is a spatial metabolomics tool for resolving tissue structures
Briefings in Bioinformatics, 2022Abstract Imaging mass spectrometry (IMS) is one of the powerful tools in spatial metabolomics for obtaining metabolite data and probing the internal microenvironment of organisms. It has dramatically advanced the understanding of the structure of biological tissues and the drug treatment of diseases.
Kaixuan Xiao +3 more
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Journal of Agricultural and Food Chemistry, 2021
In the current era of global climate change, environmental stresses, especially drought and salt, have impaired the growth and productivity of crops, e.g., cotton. Understanding the mechanisms of plants' adaptation to these abiotic stresses is crucial to breed stress-tolerant crop species.
Bingbing Liu +3 more
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In the current era of global climate change, environmental stresses, especially drought and salt, have impaired the growth and productivity of crops, e.g., cotton. Understanding the mechanisms of plants' adaptation to these abiotic stresses is crucial to breed stress-tolerant crop species.
Bingbing Liu +3 more
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Metabolomics, 2021
Muscle invasive bladder cancer (MIBC) is an advanced stage of bladder cancer which poses a severe threat to life. Cancer development is usually accompanied by remarkable alterations in cell metabolism, and hence deep insights into MIBC at the metabolomic level can facilitate the understanding of the biochemical mechanisms involved in the cancer ...
Anqi Tu, Neveen Said, David C. Muddiman
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Muscle invasive bladder cancer (MIBC) is an advanced stage of bladder cancer which poses a severe threat to life. Cancer development is usually accompanied by remarkable alterations in cell metabolism, and hence deep insights into MIBC at the metabolomic level can facilitate the understanding of the biochemical mechanisms involved in the cancer ...
Anqi Tu, Neveen Said, David C. Muddiman
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Drug Metabolism and Disposition, 2023
Mass spectrometric imaging is a nontargeted, tag-free, high-throughput, and highly responsive analytical approach. The highly accurate molecular visualization detection technology enables qualitative and quantitative analyses of biologic tissues or cells scanned by mass spectrometry in situ, extracting known and unknown multiple compounds, and ...
Yu, Chen +6 more
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Mass spectrometric imaging is a nontargeted, tag-free, high-throughput, and highly responsive analytical approach. The highly accurate molecular visualization detection technology enables qualitative and quantitative analyses of biologic tissues or cells scanned by mass spectrometry in situ, extracting known and unknown multiple compounds, and ...
Yu, Chen +6 more
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Spatially Resolved Metabolomics Reveals Metabolic Heterogeneity Among Pulmonary Fibrosis
Journal of Mass SpectrometryABSTRACT Pulmonary fibrosis (PF) is a chronic and progressive lung disease with fatal consequences. The study of PF is challenging due to the complex mechanism involved, the need to understand the heterogeneity and spatial organization within lung tissues.
Shengxi Li +8 more
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Advancing multi-day ex vivo kidney perfusion using spatially resolved metabolomics
2023ABSTRACT The ability to preserve metabolically active kidneys ex vivo for multiple days may permit reconditioning, repair and regeneration of deceased donor kidneys. However, the kidneys high metabolic demand limits its functional preservation.
Marlon J.A. de Haan +18 more
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Current Opinion in Chemical Biology, 2017
Spatial information in the form of 3D digital content has been increasingly integrated into our daily lives. Metabolomic studies parallel this trend with spatial and time resolved information being acquired. Mass spectrometry imaging (MSI), which combines qualitative and quantitative molecular information with spatial information, plays a crucial role ...
Petras, Daniel +2 more
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Spatial information in the form of 3D digital content has been increasingly integrated into our daily lives. Metabolomic studies parallel this trend with spatial and time resolved information being acquired. Mass spectrometry imaging (MSI), which combines qualitative and quantitative molecular information with spatial information, plays a crucial role ...
Petras, Daniel +2 more
openaire +2 more sources
Small Methods
AbstractSurface‐assisted laser desorption/ionization (SALDI) mass spectrometry imaging (MSI) holds great value in spatial metabolomics and tumor diagnosis. Tissue imprinting on the SALDI target can avoid laser‐induced tissue ablation and simplifies the sample preparation.
Xingyue Liu +7 more
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AbstractSurface‐assisted laser desorption/ionization (SALDI) mass spectrometry imaging (MSI) holds great value in spatial metabolomics and tumor diagnosis. Tissue imprinting on the SALDI target can avoid laser‐induced tissue ablation and simplifies the sample preparation.
Xingyue Liu +7 more
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Spatially and Temporally Resolved Metabolome of the Oral Human Cavity
2023Alessio Ciurli +7 more
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