Results 31 to 40 of about 3,488 (219)

Spatially Resolved Mass Spectrometry at the Single Cell: Recent Innovations in Proteomics and Metabolomics

Journal of the American Society for Mass Spectrometry, 2021
Biological systems are composed of heterogeneous populations of cells that intercommunicate to form a functional living tissue. Biological function varies greatly across populations of cells, as each single cell has a unique transcriptome, proteome, and metabolome that translates to functional differences within single species and across kingdoms. Over
Michael J. Taylor, Jessica K. Lukowski, Christopher R. Anderton   +2 more
openaire   +2 more sources

Applications of spatially resolved omics in the field of endocrine tumors

Frontiers in Endocrinology, 2023
Endocrine tumors derive from endocrine cells with high heterogeneity in function, structure and embryology, and are characteristic of a marked diversity and tissue heterogeneity.
Yinuo Hou, Yan Gao, Shudi Guo, Zhibin Zhang, Ruibing Chen, Xiangyang Zhang   +5 more
doaj   +1 more source

Application of MALDI mass spectrometry for spatially resolved, untargeted metabolomics [PDF]

, 2022
The field of metabolism research evaluates the molecular basis of many important phenomena in biology and medicine, ranging from cellular function to systemic-level metabolic diseases. Spatial metabolomics investigates these phenomena in situ, by mapping metabolites in their native spatial context.
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Comparison of Local Metabolic Changes in Diabetic Rodent Kidneys Using Mass Spectrometry Imaging

Metabolites, 2023
Understanding the renal region-specific metabolic alteration in different animal models of diabetic nephropathy (DN) is critical for uncovering the underlying mechanisms and for developing effective treatments.
Xin Zhang, Yanhua Liu, Shu Yang, Xin Gao, Shuo Wang, Zhaoying Wang, Chen Zhang, Zhi Zhou, Yanhua Chen, Zhonghua Wang, Zeper Abliz   +10 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Spatially and temporally resolved metabolome of the human oral cavity

iScience
Saliva is a complex bodily fluid composed of secretions by major and minor salivary glands. Salivary glands and their secretions are known to be unevenly distributed in the human oral cavity. Moreover, saliva flow rate and composition vary across locations and time of the day. This remarkable heterogeneity of salivary secretions suggests that different
Ciurli, A., Mohammed, Y., Ammon, C., Derks, R.J.E., Olivier-Jimenez, D., Ducarmon, Q.R., Slingerland, M., Neefjes, J.J.C., Giera, M.   +8 more
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Untargeted and spatial-resolved metabolomics characterize serum and tissue-specific metabolic reprogramming in acute kidney injury

Heliyon, 2023
Acute kidney injury (AKI) is one of the most common clinical emergencies characterized by rapid progression, difficulty in early diagnosis, and high mortality. Currently, there are no effective AKI early diagnostic methods and treatments. Therefore, identifying new mechanisms of AKI have become urgent for development new targets for early diagnosis and
Bei Xu, Wanyi Li, Yamei Zhang, Yan Chen, Jiafu Feng, Xiangrong Song   +5 more
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Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

In situ metabolomics in nephrotoxicity of aristolochic acids based on air flow-assisted desorption electrospray ionization mass spectrometry imaging

Acta Pharmaceutica Sinica B, 2020
Understanding of the nephrotoxicity induced by drug candidates is vital to drug discovery and development. Herein, an in situ metabolomics method based on air flow-assisted desorption electrospray ionization mass spectrometry imaging (AFADESI-MSI) was ...
Zhonghua Wang, Bingshu He, Yaqi Liu, Meiling Huo, Wenqing Fu, Chunyan Yang, Jinfeng Wei, Zeper Abliz   +7 more
doaj   +1 more source

SMART: An Approach for Accurate Formula Assignment in Spatially Resolved Metabolomics

Analytical Chemistry
Abstract Spatially-resolved metabolomics plays a critical role in unraveling tissue-specific metabolic complexities. Despite its significance, this profound technology generates thousands of features, yet accurate annotation significantly lags behind LC-MS-based approaches.
Yinghao Cao, Shengxi Li, Zhaoyi Liu, Zixian Jia, Weidong Zhuang, Xu Pan, Jinyu Zhou, Lifeng Yang, Lin Wang   +8 more
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