Discovering metabolic vulnerability using spatially resolved metabolomics for antitumor small molecule-drug conjugates development as a precise cancer therapy strategy [PDF]
Journal of Pharmaceutical Analysis, 2023 Against tumor-dependent metabolic vulnerability is an attractive strategy for tumor-targeted therapy. However, metabolic inhibitors are limited by the drug resistance of cancerous cells due to their metabolic plasticity and heterogeneity. Herein, choline
Xiangyi Wang +9 more
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Unveiling the anticancer potential of flavonoids in hepatocellular carcinoma through microbiome and spatially resolved metabolomics analysis [PDF]
Discover OncologyBackground Hepatocellular carcinoma (HCC) causes a large worldwide health burden, needing novel ways to prevention and treatment. Traditional Chinese medicine, which is rich in bioactive substances, has emerged as a viable approach to tackling HCC ...
Lina You, WuKui Huang, ShuYing Chen
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Spatially resolved integrative analysis of transcriptomic and metabolomic changes in tissue injury studies [PDF]
Nature CommunicationsRecent developments in spatially resolved -omics have enabled the joint study of gene expression, metabolite levels and tissue morphology, offering greater insights into biological pathways.
Eleanor C. Williams +20 more
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Spatially Resolved Metabolomic Profiling Reveals Progression-Associated Metabolic Reprogramming in Colorectal Liver Metastasis [PDF]
MetabolitesBackground/Objectives: Colorectal cancer (CRC) is a leading cause of cancer-related mortality, with colorectal liver metastasis (CRLM) being the major determinant of poor prognosis.
Ying Zhu +8 more
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Toward spatially resolved metabolomics. [PDF]
Nat Chem Biol, 2020 Coherent Raman imaging enables mapping of chemical features at subcellular resolution, setting the stage for tracking lipids and other metabolites in intact living systems.
Fox BW, Schroeder FC.
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Toward Gene-Correlated Spatially Resolved Metabolomics with Fingerprint Coherent Raman Imaging. [PDF]
J Phys Chem B, 2023 Raman spectroscopy has long been known to provide sufficient information to discriminate distinct cell phenotypes. Underlying this discriminating capability is that Raman spectra provide an overall readout of the metabolic profiles that change with transcriptomic activity.
Poorna R, Chen WW, Qiu P, Cicerone MT.
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Correction to "Toward Gene-Correlated Spatially Resolved Metabolomics with Fingerprint Coherent Raman Imaging". [PDF]
J Phys Chem B, 2023 International ...
Poorna R +4 more
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Spatially Resolved Metabolomics and Network Pharmacology Reveal Extract D Nephrotoxicity Mechanisms in Pleuropterus multiflorus Thunb. [PDF]
ToxicsAs a traditional Chinese medicine, the adverse hepatotoxicity effects of Pleuropterus multiflorus (Thunb.) Nakai (PM) have been documented. However, nephrotoxicity has been neglected as studies related to kidney toxicity mechanisms are limited.
Haiyan Jiang +9 more
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Spatially resolved metabolomics visualizes heterogeneous distribution of metabolites in lung tissue and the anti-pulmonary fibrosis effect of Prismatomeris connate extract [PDF]
Journal of Pharmaceutical AnalysisPulmonary fibrosis (PF) is a chronic progressive end-stage lung disease. However, the mechanisms underlying the progression of this disease remain elusive. Presently, clinically employed drugs are scarce for the treatment of PF. Hence, there is an urgent
Haiyan Jiang +12 more
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Spatially Resolved Multiomics Reveals Metabolic Remodeling and Autophagy Activation in Adamantinomatous Craniopharyngiomas [PDF]
Advanced ScienceAdamantinomatous craniopharyngioma (ACP), a benign yet highly recurrent and therapy—resistant intracranial tumor, remains a considerable clinical challenge because of its complex pathological structure, infiltrative growth, and limited treatment options.
Dongting Chen +9 more
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