Results 21 to 30 of about 3,488 (219)
Spatially resolved metabolomic dataset of distinct human kidney anatomic regions
Data in BriefCortex, medulla and papilla are three major human kidney anatomic structures and they harbour unique metabolic functions, but the underlying metabolomic profiles are largely unknown at spatial resolution.
Haikuo Li, Benjamin D. Humphreys
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Challenges of Spatially Resolved Metabolism in Cancer Research
MetabolitesStable isotope-resolved metabolomics comprises a critical set of technologies that can be applied to a wide variety of systems, from isolated cells to whole organisms, to define metabolic pathway usage and responses to perturbations such as drugs or ...
Andrew N. Lane +2 more
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Artificial Intelligence for Spatial Immunometabolic Analysis of the Tumor Microenvironment: Current Evidence and Future Directions [PDF]
Current Issues in Molecular BiologyThe tumor microenvironment [TME] is a dynamic ecosystem where spatial organization and metabolic reprogramming play a crucial role in immune response, tumor progression, and therapeutic response.
Ismail Abdullah +7 more
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Spatially resolved 3D metabolomic profiling in tissues [PDF]
Science Advances, 2021 Spatially resolved metabolic profiling and isotope-tagged protein analysis revealed unique lipid distributions in tissues.
Shambavi Ganesh +6 more
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Bulk and spatially resolved extracellular metabolomics of free-living nitrogen fixation [PDF]
Applied and Environmental Microbiology, 2022 Abstract Soil microorganisms drive ecosystem function, but challenges of scale between microbe and ecosystem hinder our ability to accurately quantify and predictively model the soil microbe-ecosystem function relationship. Quantifying this relationship necessitates studies that systematically characterize multi-omics
Darian N. Smercina +4 more
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Promise of spatially resolved omics for tumor research
Journal of Pharmaceutical Analysis, 2023 Tumors are spatially heterogeneous tissues that comprise numerous cell types with intricate structures. By interacting with the microenvironment, tumor cells undergo dynamic changes in gene expression and metabolism, resulting in spatiotemporal ...
Yanhe Zhou +6 more
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Spatially resolved sampling of the human oral cavity for metabolic profiling
STAR Protocols, 2021 Summary: Here, we present a spatially resolved sampling protocol for the oral human cavity aimed at untargeted metabolomics. We describe the spatial collection of salivary biospecimens, their preparation, and subsequent mass-spectrometry-based untargeted
Alessio Ciurli +5 more
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Characterization of metabolic compartmentalization in the liver using spatially resolved metabolomics [PDF]
, 2021 Abstract Cells adapt their metabolism to physiological stimuli, and metabolic heterogeneity exists between cell types, within tissues, and subcellular compartments. The liver plays an essential role in maintaining whole-body metabolic homeostasis and is structurally defined by metabolic zones.
Jiska van der Reest +7 more
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Nature Communications, 2023 Metabolic reprogramming in cancer and immune cells occurs to support their increasing energy needs in biological tissues. Here we propose Single Cell Spatially resolved Metabolic (scSpaMet) framework for joint protein-metabolite profiling of single ...
Thomas Hu +9 more
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Dissecting the brain with spatially resolved multi-omics
Journal of Pharmaceutical Analysis, 2023 Recent studies have highlighted spatially resolved multi-omics technologies, including spatial genomics, transcriptomics, proteomics, and metabolomics, as powerful tools to decipher the spatial heterogeneity of the brain.
Yijia Fangma +4 more
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