Spatially resolved metabolomics: From metabolite mapping to function visualising [PDF]
Clinical and Translational MedicineMass spectrometry imaging (MSI)‐based spatially resolved metabolomics addresses the limitations inherent in traditional liquid chromatography‐tandem mass spectrometry (LC–MS)‐based metabolomics, particularly the loss of spatial context within ...
Xinyue Min +10 more
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Combined spatially resolved metabolomics and spatial transcriptomics reveal the mechanism of RACK1‐mediated fatty acid synthesis [PDF]
Molecular OncologyLipid metabolism is altered in rapidly proliferating cancer cells, where fatty acids (FAs) are utilized in the synthesis of sphingolipids and glycerophospholipids to produce cell membranes and signaling molecules. Receptor for activated C‐kinase 1 (RACK1;
Lixiu Xu +3 more
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Spatially Resolved Plant Metabolomics [PDF]
MetabolitesResearch and innovation in metabolomics tools to measure metabolite accumulation within plants have led to important discoveries with respect to the improvement of plant stress tolerance, development, and crop yield.
Ronald J. Myers +14 more
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Spatially resolved sampling for untargeted metabolomics: A new tool for salivomics [PDF]
iScience, 2021 Summary: Saliva is a complex bodily fluid composed of metabolites secreted by major and minor glands, as well as by-products of host oral cells, oral bacteria, gingival crevicular fluid, and exogenous compounds.
Alessio Ciurli +4 more
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Molecular Pathological Diagnosis of Thyroid Tumors Using Spatially Resolved Metabolomics [PDF]
Molecules, 2022 The pathological diagnosis of benign and malignant follicular thyroid tumors remains a major challenge using the current histopathological technique.
Luojiao Huang +10 more
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A Comprehensive Spatially Resolved Metabolomics Dataset for Lampreys [PDF]
Scientific DataAs one of the two most ancient groups of extant vertebrates, lamprey has become an important model organism in various fields of biology. In this paper, we present a comprehensive tissue-wide spatial metabolomics dataset for lampreys, where 14 distinct ...
Meng Gou +5 more
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Evaluation of Formalin-Fixed and FFPE Tissues for Spatially Resolved Metabolomics and Drug Distribution Studies [PDF]
Pharmaceuticals, 2022 Fixation of samples is broadly used prior to the histological evaluation of tissue samples. Though recent reports demonstrated the ability to use fixed tissues for mass spectrometry imaging (MSI) based proteomics, glycomics and tumor classification ...
Andreas Dannhorn +7 more
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Microbiome and spatially resolved metabolomics analysis reveal the anticancer role of gut Akkermansia muciniphila by crosstalk with intratumoral microbiota and reprogramming tumoral metabolism in mice [PDF]
Gut Microbes, 2023 Although gut microbiota has been linked to cancer, little is known about the crosstalk between gut- and intratumoral-microbiomes. The goal of this study was to determine whether gut Akkermansia muciniphila (Akk) is involved in the regulation of ...
Zhuxian Zhu +8 more
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Spatially resolved metabolomics reveals variety-specific metabolic changes in banana pulp during postharvest senescence [PDF]
Food Chemistry: X, 2022 Banana is one of most popular fruits globally due to health-promoting and disease-preventing effects, yet little is known about in situ metabolic changes across banana varieties.
Zhibin Yin +7 more
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Spatially resolved metabolomics to discover tumor-associated metabolic alterations [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance Tumor cells reprogram their metabolism to support cell growth, proliferation, and differentiation, thus driving cancer progression. Profiling of the metabolic signatures in heterogeneous tumors facilitates the understanding of tumor metabolism and introduces potential metabolic vulnerabilities that might be targeted ...
Ruiping Zhang, Nan Bi, Qingce Zang
exaly +5 more sources