Results 61 to 70 of about 11,140,077 (397)

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini   +10 more
wiley   +1 more source

Meta analysis for special education leadership in Malaysia [PDF]

open access: yes, 2020
The leadership of the headmaster as the school's chief administrator is crucial in determining the school's direction of success. Practiced leadership also reflects school culture and teachers' performance. This will help to ensure the success of the
Abdul Razzaq, Abdul Rasid   +4 more
core  

Investigating the Impact of Universal Design for Learning: Empowering Students with Disabilities in Higher Education [PDF]

open access: yesE3S Web of Conferences
Universal Design for Learning (UDL) seeks to improve accessibility in the classroom and offer diverse students classroom experiences that are proactively designed to be flexible and inclusive for all students.
Novembli Meta Silfia   +2 more
doaj   +1 more source

Nutritional needs of children with disabilities in the UAE: understanding predictors and mediators of nutritional knowledge and practices

open access: yesBMC Nutrition, 2022
Background There is a high estimated prevalence of obesity and poor eating habits among children with disabilities. Unfortunately, the extent of parental and teachers’ awareness of the dietary needs and nutritional requirements of children with ...
Maxwell Peprah Opoku   +7 more
doaj   +1 more source

North-South collaboration: On the making of a Center for Comparative Education and Policy Studies at Addis Ababa University

open access: yesNordic Journal of Comparative and International Education, 2021
The Ethiopian educational system has made promising advancements since the turn of the century. Despite this progress, education continues to grapple with a myriad of challenges, including differences in educational access and quality, insecure living ...
Alebachew Kemisso Haybano   +3 more
doaj   +1 more source

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

open access: yesMolecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim   +8 more
wiley   +1 more source

The development and validation of the intercultural communicative competence evaluation instrument (ICCEI)

open access: yesCogent Education
English foreign language (EFL) teachers’ intercultural communicative competence (ICC) is crucial for effective culturally responsive language learning and learners’ development of ICC.
K. Tsatzali   +4 more
doaj   +1 more source

Maternal Communicative Behavior as a Factor in the Development of Communication in Children with Down Syndrome [PDF]

open access: yesPsychology in Russia: State of Art, 2018
Background. Special features of communicative development in children with Down Syndrome are reported to correlate with intellectual disability, while their mothers’ communication with them is considered to be a reaction to difculties in building ...
Yulia A. Razenkova   +2 more
doaj   +1 more source

Special Educational Needs and Evaluation [PDF]

open access: yesProcedia - Social and Behavioral Sciences, 2013
AbstractThe italian school is dealing with the matter of the evaluation of Special Educational Needs (SED). Since there are no legislative references that indicate which procedures to follow, it is left to the teachers’ discretion. Recent ministerial documents, though, suggest to refer to the existing normative on Specific Learning Disturbances, in ...
ARDUINI, Giovanni, D. Chiusaroli
openaire   +2 more sources

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

open access: yesMolecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka   +10 more
wiley   +1 more source

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