Results 61 to 70 of about 639,854 (264)
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
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Combining ability of sugarcane genotypes based on the selection rates of single cross families
Crop Breeding and Applied Biotechnology, 2017 This study evaluated the genetic potential of parents used in sugarcane genetic breeding programs based on the performance of previously conducted single crosses. The average selection rate of each family, predicted using Best Linear Unbiased Prediction (
Lázaro José Chaves +2 more
doaj
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
The human gut microbiome across the life course
FEBS Letters, EarlyView.Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source
Use of a Full Diallel Cross to Estimate General and Specific Combining Ability in Chickens ,
Poultry Science, 1965 Abstract INTRODUCTION THE diallel cross has become a common method of analyzing intra-specific genetic variability among crosses (partial diallel) or among parental subpopulations and their crosses (full diallel). The breeder needs the full diallel to determine whether crossing per se is of value in improving productivity.
S, WEARDEN, D, TINDELL, J V, CRAIG
openaire +2 more sources
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
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Components of Specific Combining Ability Estimated from Strain and Breed Crosses in Chickens ,
Poultry Science, 1967 Abstract INTRODUCTION HETEROSIS, the increase in performance of crosses over parental strains, has generally been found in fowl for chick livability, early growth rate, age at sexual maturity, egg production and at times for adult livability. Degree of heterosis seems to be positively associated with genetic diversity of the parental strains.
S, Wearden, J V, Craig, D, Tindell
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FEBS Letters, EarlyView.The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source