Results 91 to 100 of about 485,685 (298)

Temporal and Cell‐Specific Regulation of Synaptic Homeostasis by the Chromatin Remodeler Chd1

Advanced Science, EarlyView.
Chd1, the Drosophila homologue of mammalian CHD2 ‐ a gene linked to autism, epilepsy, and intellectual disability, is required for synaptic homeostatic plasticity. Chd1 in glia is necessary for the rapid induction of synaptic homeostasis, whereas Chd1 in motoneurons, muscle, and glia is critical for long‐term maintenance.
Danielle T. Morency, Tao Cui, Yimei Cai, Chloe Lok, Rachel E. Nokku, Ruoxian Huang, Grace L. Chu, Yumeng Xie, Saleem W. Abu‐Tayeh, Kaikai He, Chengjie Qiu, Junyi Wang, Paxton M. Paganelli, Ting Wang, Gabrielle Williams, Sreejith Nair, Huadong Pei, Dion K. Dickman, Stefano Vicini, Tingting Wang   +19 more
wiley   +1 more source

Promise for the Future: How Federal Programs Can Improve Career Outcomes for Youth & Young Adults with Serious Mental Health Conditions [PDF]

, 2013
This report focuses on a critical area of mental health policy – how to assist youth and young adults with serious mental health conditions with improved prospects for successful independent living and economic security through education, job training ...
Chris Koyanagi, Elaine Alfano
core  

Differentiation in the foreign language classroom : including students with disabilities in secondary foreign language classes [PDF]

, 2015
textForeign language teachers are not generally given information about how to work with students with disabilities. However, it is important for these students to have access to FL classes, both for the cognitive benefits that they offer and for path ...
Trawick, Jessie Elisabeth
core   +1 more source

Zinc Exposure Causes Disulfidptosis to Induce Miscarriage by Up‐Regulating GATA1/METTL1/SLC7A11 Axis

Advanced Science, EarlyView.
Zn exposure up‐regulates GATA1, promoting GATA1‐mediated METTL1 and SLC7A11 transcription. It also enhances METTL1‐mediated m7G modification on SLC7A11 mRNA, increasing SLC7A11 mRNA stability. Ultimately, Zn exposure up‐regulates SLC7A11 at both transcriptional and post‐transcriptional levels, causing disulfidptosis. Knockdown of murine Slc7a11, Gata1,
Wenxin Huang, Yi Sun, Yanxin Wang, Haijun Yan, Xiaoping Yue, Weidong Wu, Xueyu Chen, Jinfang Zhang, Yanbing Lin, Qiong Lei, Nan Ji, Shuaishuai Xing, Liqin Zeng, Qingzheng Kang, Depeng Zhao, Geng Guo, Huidong Zhang   +16 more
wiley   +1 more source

Digital accessibility by students with disabilities: A pressing need in South African higher education

African Journal of Teacher Education
All diverse students need digital accessibility for them to be enabled meaningful learning in the present digital era in the African higher education at large, and in South African context specifically.
Sibonokuhle Ndlovu
doaj   +1 more source

Guideposts For Success [PDF]

, 2006
[Excerpt] he transition from youth to adulthood is challenging for almost every young person. This is particularly true for young people with disabilities.
National Center on Workforce and Disability/Youth
core   +1 more source

Long-term condition management in adults with intellectual disability in primary care: a systematic review [PDF]

, 2018
Background: Adults with intellectual disabilities have higher morbidity and earlier mortality than the general population. Access to primary health care is lower, despite a higher prevalence of many long-term conditions.
Allan, Linda, Cooper, Sally-Ann, Hanlon, Peter, Macdonald, Sara, Wood, Karen   +4 more
core   +1 more source

Understanding and Overcoming Antibody‐Drug Conjugate Resistance: Biological Mechanisms and Emerging Analytical Frameworks in Breast Cancer

Advanced Science, EarlyView.
Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley   +1 more source

Teachers’ Perception of the Relationship With Pupils Having Specific Learning Disabilities

Interpersona: An International Journal on Personal Relationships, 2013
Research Findings: The presence of Specific Learning Disabilities (SLD) increases the risk of scholastic failure. According to the literature, a successful relationship with the teacher can lead to greater participation, raise the pupil’s motivation in ...
Tiziana Pasta, Manuela Mendola, Laura Elvira Prino, Claudio Longobardi, Francesca Giovanna Maria Gastaldi   +4 more
doaj   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source