Results 101 to 110 of about 5,602,543 (311)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Drug resistance to sulphadoxine-pyrimethamine in Plasmodium falciparum malaria in Mlimba, Tanzania. [PDF]

, 2006
BACKGROUND\ud \ud Sulphadoxine-pyrimethamine (SP) has been and is currently used for treatment of uncomplicated Plasmodium falciparum malaria in many African countries.
Mbugi, Erasto V, Balthazary Sakurani T, Malisa, Allen L, Mbugi Erasto V, Allen L Malisa, Nyambo, Thomas B, Nyambo, T.B., Mutayoba, B.M., Mutayoba Benezeth M, Nyambo Thomas B, Balthazary, Sakurani T, Erasto V Mbugi, Balthazary, S.T., Hassan Mshinda, Mshinda, H., Mshinda Hassan, Benezeth M Mutayoba, Sakurani T Balthazary, Malisa Allen L, Mutayoba, Benezeth M, Mbugi, E.V., Thomas B Nyambo, Mshinda, Hassan, Malisa, A.L.   +23 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Novel Relationship Between Breakdown Voltage and Specific On-Resistance of Accumulation-Mode VDMOS

IEEE Journal of the Electron Devices Society
This paper systematically quantifies the operating mechanism of accumulation-mode vertical double-diffused metal-oxide-semiconductor field-effect transistors (Ac VDMOS) and establishes an analytical model for the relationship between breakdown voltage ( $
Baoxing Duan, Jidong Jiao, Haitao Song, Yintang Yang   +3 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Successive increases in the resistance of Drosophila to viral infection through a transposon insertion followed by a Duplication [PDF]

, 2011
To understand the molecular basis of how hosts evolve resistance to their parasites, we have investigated the genes that cause variation in the susceptibility of Drosophila melanogaster to viral infection.
Magwire, Michael M, Claire L Webster, Bayer, Florian, Michael M Magwire, Cao Chuan, Francis M. Jiggins, Webster Claire L., Florian Bayer, Francis M Jiggins, Bayer Florian, Jiggins, Francis M, Chuan Cao, Cao, Chuan, Jiggins Francis M., Claire L. Webster, Webster, Claire L, Magwire Michael M., Michael M. Magwire   +17 more
core   +2 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Rejuvenation : official journal of the International association on the artificial prolongation of the human specific lifespan. [PDF]

Voortzetting van: Official journal of the International association on the artificial prolongation of the human specific lifespan [ISSN 0301 ...
International association on the artifical prolongation of the human specific lifespan
core  

Using allele-specific oligonucleotide probes to characterize benzimidazole resistance in Rhynchosporium secalis [PDF]

, 1995
Benzimidazole fungicides are important mixture components in strategies to combat fungicide resistance in Rhynchosporium secalis Davis. To monitor the performance of these strategies, a rapid, accurate assay has been developed to detect point mutations ...
Hollomon, D. W., Butters, J., Wheeler, J. E., Kendall, S. J., Hall, L.   +4 more
core  

Design considerations of high voltage RESURF nLDMOS: An analytical and numerical study

Ain Shams Engineering Journal, 2015
In this paper, a RESURF high voltage (HV) nLDMOS is designed in 0.35 μm BiCMOS technology (STMicroelectronics technology-like). Optimization of the key device/process parameters of the device is performed using analytical approach and verified using ...
Mohamed Abouelatta-Ebrahim, Ahmed Shaker, Gihan T. Sayah, Christian Gontrand, Abdelhalim Zekry   +4 more
doaj   +1 more source