Results 81 to 90 of about 72,291,708 (309)
Hsp90 governs dispersion and drug resistance of fungal biofilms [PDF]
, 2011 Fungal biofilms are a major cause of human mortality and are recalcitrant to most treatments due to intrinsic drug resistance. These complex communities of multiple cell types form on indwelling medical devices and their eradication often requires ...
Ramage Gordon +25 more
core +2 more sources
An Improved 4H-SiC Trench MOS Barrier Schottky Diode With Lower On-Resistance
IEEE Access, 2019 An improved 4H-SiC trench MOS barrier Schottky (TMBS) structure that can significantly reduce the specific on-resistance ( $R_{on,sp}$ ) is proposed in this paper.
Fei Cao +5 more
doaj +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Lack of phenotypic and evolutionary cross-resistance against parasitoids and pathogens in Drosophila melanogaster [PDF]
, 2012 BackgroundWhen organisms are attacked by multiple natural enemies, the evolution of a resistance mechanism to one natural enemy will be influenced by the degree of cross-resistance to another natural enemy.
Futerman Peter H. +15 more
core +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
, 2011 The whitefly, Bemisia tabaci (Hemiptera: Aleyrodidae), is an invasive insect pest of agriculture and horticulture worldwide. The neonicotinoid insecticides, which target nicotinic acetylcholine receptors in post-synaptic nerve membranes, play a major ...
Jones, C. M. +15 more
core +1 more source
The integrated concept of disease resistance; a new view including horizontal and vertical resistance in plants [PDF]
, 1977 Horizontal, uniform, race-non-specific or stable resistance can be discerned according to Van der Plank, from vertical, differential, race-specific or unstable resistance by a test in which a number of host genotypes (cultivars or clones) are tested ...
Zadoks, J.C., Parlevliet, J.E.
core +1 more source
Journal of Fungi, 2018 Antifungal resistance is a topic of concern, particularly for specific fungal species and drugs. Among these are the multidrug-resistant Candida auris and azole-resistant Aspergillus fumigatus. While the knowledge on molecular mechanisms of resistance is
Sevtap Arikan-Akdagli +2 more
doaj +1 more source
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
Antimicrobial drug use and resistance in Europe [PDF]
, 2008 Our study confronts the use of antimicrobial agents in ambulatory care with the resistance trends of 2 major pathogens, Streptococcus pneumoniae and Escherichia coli, in 21 European countries in 2000–2005 and explores whether the notion that ...
Grundmann, Hajo +8 more
core +1 more source