Results 31 to 40 of about 4,525,804 (339)
Small Molecules for Enhancing the Precision and Safety of Genome Editing
Clustered regularly interspaced short palindromic repeats (CRISPR)-based genome-editing technologies have revolutionized biology, biotechnology, and medicine, and have spurred the development of new therapeutic modalities.
Siyoon Shin, Seeun Jang, Donghyun Lim
doaj +1 more source
Specificity is a relevance dimension that describes the extent to which a document part focuses on the topic of request. In the context of semi-structured text (XML) retrieval, a document part corresponds to an XML element. Specificity is defined as the length ratio, typically in number of characters, of contained relevant to irrelevant text in the ...
Pehcevski, Jovan, Piwowarski, Benjamin
openaire +2 more sources
Facile Affinity Maturation of Antibody Variable Domains Using Natural Diversity Mutagenesis
The identification of mutations that enhance antibody affinity while maintaining high antibody specificity and stability is a time-consuming and laborious process.
Kathryn E. Tiller +6 more
doaj +1 more source
Validity and practical utility of accelerometry for the measurement of in-hand physical activity in horses [PDF]
Background: Accelerometers are valid, practical and reliable tools for the measurement of habitual physical activity (PA). Quantification of PA in horses is desirable for use in research and clinical settings. The objective of this study was to evaluate
Carnwath, J. +6 more
core +2 more sources
Post-Mortem diagnosis of dementia by informant interview. [PDF]
The diagnosis of normal cognition or dementia in the Brazilian Brain Bank of the Aging Brain Study Group (BBBABSG) has relied on postmortem interview with an informant. Objectives:To ascertain the sensitivity and specificity of postmortem diagnosis based
Balbino, Érika Silvério +19 more
core +2 more sources
Improving hemodialysis patient depression outcomes with acupuncture: A randomized controlled trial
Objective: To evaluate the efficacy and safety of acupuncture as a supplementary treatment for mild to moderate depression in hemodialysis patients. Method: This multicenter, randomized, controlled, single-masked trial included 64 hemodialysis patients ...
Xijing Yu +4 more
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This paper is concerned with semantic noun phrase typology, focusing on the question of how to draw fine-grained distinctions necessary for an accurate account of natural language phenomena.
Farkas, Donka F.
core
Sensitivity and Specificity of the Comfort Scale to Assess Pain in Ventilated Critically Ill Adult Patients in Intensive Care Unit [PDF]
Background: Pain is a common phenomenon experienced by ventilated and critically ill adult patients. It is urgent to measure the pain among these patients since they are unable to report their pain verbally.
Prasetyo, A. (Awal) +2 more
core +1 more source
The unpredictably eruptive dynamics of spruce budworm populations in eastern Canada
We examine historical population data for spruce budworm from several locations through the period 1930–1997, and use density‐dependent recruitment curves to test whether the pattern of population growth over time is more consistent with Royama's (1984; Ecological Monographs 54:429–462) linear R(t) model of harmonic oscillation at Green River New ...
Barry J. Cooke, Jacques Régnière
wiley +1 more source
Background: Long-snake moxibustion can improve hypothalamic-pituitary-adrenal (HPA) axis function in patients with kidney-yang deficiency (KYDS). 11β-HSD1 controls the HPA axis by boosting CORT production via reductase activity.
Hui Huang +9 more
doaj +1 more source

