Results 41 to 50 of about 2,010,640 (293)
FoxO1 signaling in B cell malignancies and its therapeutic targeting
FEBS Letters, EarlyView.FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac +3 more
wiley +1 more source
Effect of non-specific interactions on formation and stability of specific complexes [PDF]
, 2016 We introduce a simple model to describe the interplay between specific and non-specific interactions. We study the influence of various physical factors on the static and dynamic properties of the specific interactions of our model and show that contrary to intuitive expectations, non-specific interactions can assist in the formation of specific ...
arxiv +1 more source
Learning Objectives, Insights, and Assessments: How Specification Formats Impact Design [PDF]
arXiv, 2021 Despite the ubiquity of communicative visualizations, specifying communicative intent during design is ad hoc. Whether we are selecting from a set of visualizations, commissioning someone to produce them, or creating them ourselves, an effective way of specifying intent can help guide this process.
arxiv
FEBS Letters, EarlyView.Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi +3 more
wiley +1 more source
Acta Medica Martiniana, 2013 Cough is the most common symptom of many respiratory diseases. Currently, no standardized methods exist for objective monitoring of cough, which could be commercially available and clinically acceptable.
Martinek Jozef +5 more
doaj +1 more source
Indian Journal of Ophthalmology, 2013 Purpose: To evaluate frequency and severity of segmentation errors of two spectral-domain optical coherence tomography (SD-OCT) devices and error effect on central macular thickness (CMT) measurements.
Moosang Kim +4 more
doaj +1 more source
eLife, 2020 Protein-protein interaction specificity is often encoded at the primary sequence level. However, the contributions of individual residues to specificity are usually poorly understood and often obscured by mutational robustness, sequence degeneracy, and ...
Thuy-Lan V Lite +5 more
doaj +1 more source
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Performance of 2 Commercial Serologic Tests for Diagnosing Zika Virus Infection
Emerging Infectious Diseases, 2019 Reliable serologic tests are needed for diagnosis and surveillance of Zika virus infection. We evaluated the Euroimmun and Dia.Pro serologic tests for detection of Zika virus IgM and IgG by using a panel of 199 samples from a region endemic for ...
Séverine Matheus +7 more
doaj +1 more source