Results 61 to 70 of about 218,129 (345)

Seismic Acceleration Spectrum of Ground Surface under Urban Subway Tunnels with Circular Cross Sections in Soil Deposits Based on SSI

open access: yesShock and Vibration, 2019
Underground tunnels with circular cross section nowadays have great application in the field of transportation. One of their most prominent uses is the subway, built with the help of tunnel boring machines (TBMs).
Hamed Fakhriyeh   +2 more
doaj   +1 more source

A Suzaku X-Ray Study of the Particle Acceleration Processes in the Relativistic Jet of Blazar Mrk 421

open access: yes, 2010
We report on the findings of a 364 ksec observation of the BL LAC object Mrk 421 with the X-ray observatory Suzaku. The analysis in this paper uses fluxes and hardness ratios in the broad energy range from 0.5 keV to 30 keV.
Baring, Matthew G.   +2 more
core   +1 more source

Probabilistic seismic hazard analysis using a new ground motion intensity measure

open access: yesDyna, 2016
The main objective of this work is to compute the probabilistic seismic hazard analysis for a region of Mexico using a new ground motion intensity measure which is based on the spectral acceleration and a parameter proxy of the spectral shape named Np ...
Robespiere Chávez López   +1 more
doaj   +1 more source

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

open access: yesMolecular Oncology, EarlyView.
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park   +6 more
wiley   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

open access: yesMolecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser   +11 more
wiley   +1 more source

Ground motion prediction equations based on shallow crustal earthquakes in Georgia and the surrounding Caucasus

open access: yesEarthquake Science, 2022
Strong ground motions caused by earthquakes with magnitudes ranging from 3.5 to 6.9 and hypocentral distances of up to 300 km were recorded by local broadband stations and three-component accelerograms within Georgia’s enhanced digital seismic network ...
Nato Jorjiashvili   +4 more
doaj  

Metodología de modelación de escenarios de riesgo sísmico en Managua, Nicaragua

open access: yesNexo, 2010
The research methodology for seismic risk scenarios modeling in Managua, Nicaragua was carried out by the CENTRAL AMERICA SEISMIC RISK REDUCTION PROJECT (RESIS II) in phase II under the auspices of the center for disaster prevention in Central America ...
A. Ugarte
doaj   +1 more source

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu   +11 more
wiley   +1 more source

Spectral Hardening of Large Solar Flares

open access: yes, 2008
RHESSI observations are used to quantitatively study the hard X-ray evolution in 5 large solar flares selected for spectral hardening in the course of the event.
A. O. Benz, Massaro E., P. C. Grigis
core   +1 more source

Comprehensive omics‐based classification system in adult patients with B‐cell acute lymphoblastic leukemia

open access: yesMolecular Oncology, EarlyView.
The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song   +11 more
wiley   +1 more source

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