Results 61 to 70 of about 234,218 (345)

Seismic Acceleration Spectrum of Ground Surface under Urban Subway Tunnels with Circular Cross Sections in Soil Deposits Based on SSI

Shock and Vibration, 2019
Underground tunnels with circular cross section nowadays have great application in the field of transportation. One of their most prominent uses is the subway, built with the help of tunnel boring machines (TBMs).
Hamed Fakhriyeh, Reza Vahdani, Mohsen Gerami   +2 more
doaj   +1 more source

Spectral Hardening of Large Solar Flares

, 2008
RHESSI observations are used to quantitatively study the hard X-ray evolution in 5 large solar flares selected for spectral hardening in the course of the event.
A. O. Benz, Massaro E., P. C. Grigis
core   +1 more source

Impact of Secondary Acceleration in Gamma-Ray Bursts [PDF]

, 2014
We discuss the acceleration of secondary muons, pions, and kaons in gamma-ray bursts within the internal shock scenario, and their impact on the neutrino fluxes.
Klein, Spencer R., Tjus, Julia Becker, Winter, Walter   +2 more
core   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Optimal earthquake intensity measures for probabilistic seismic demand models of ARP1400 reactor containment building

Nuclear Engineering and Technology, 2021
This study identifies efficient earthquake intensity measures (IMs) for seismic performances and fragility evaluations of the reactor containment building (RCB) in the advanced power reactor 1400 (APR1400) nuclear power plant (NPP).
Duy-Duan Nguyen, Bidhek Thusa, Md Samdani Azad, Viet-Linh Tran, Tae-Hyung Lee   +4 more
doaj   +1 more source

NekRS, a GPU-accelerated spectral element Navier–Stokes solver

Parallel Computing, 2022
14 pages, 8 ...
Paul Fischer, Stefan Kerkemeier, Misun Min, Yu-Hsiang Lan, Malachi Phillips, Thilina Rathnayake, Elia Merzari, Ananias Tomboulides, Ali Karakus, Noel Chalmers, Tim Warburton   +10 more
openaire   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Accelerated spectral clustering using graph filtering of random signals [PDF]

2016 IEEE International Conference on Acoustics, Speech and Signal Processing (ICASSP), 2016
We build upon recent advances in graph signal processing to propose a faster spectral clustering algorithm. Indeed, classical spectral clustering is based on the computation of the first k eigenvectors of the similarity matrix' Laplacian, whose computation cost, even for sparse matrices, becomes prohibitive for large datasets.
Tremblay, Nicolas, Puy, Gilles, Borgnat, Pierre, Gribonval, Rémi, Vandergheynst, Pierre   +4 more
openaire   +3 more sources

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source