Results 81 to 90 of about 1,520 (199)

Kernel Density Estimation Based Gaussian and Non-Gaussian Random Vibration Data Induction for High-Speed Train Equipment

IEEE Access, 2020
Because general statistics tolerance is not applicable to the induction of non-Gaussian vibration data and the methods for converting non-Gaussian data into Gaussian data are not always effective and can increase the estimation error, a novel kernel ...
Peng Wang, Hua Deng, Yi Min Wang, Yue Liu, Yi Zhang   +4 more
doaj   +1 more source

Accelerating Spectral Clustering under Fairness Constraints

CoRR
ICML ...
Tonin, Francesco, Lambert, Alex, Suykens, Johan, Cevher, Volkan   +3 more
openaire   +4 more sources

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Effect of terahertz irradiation on DNA damage repair in living cells

FEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno, Shota Yamazaki, Hiromichi Hoshina, Masahiko Harata   +3 more
wiley   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

A STUDY OF BUILDING PERFORMANCE INSPECTION BASED ON A COMBINATION OF SITE-SPECIFIC RESPONSE ANALYSIS AND STRUCTURAL ANALYSIS (A CASE STUDY OF THE LIGHTHOUSE VIEW TOWER IN BENGKULU CITY, INDONESIA)

Rudarsko-geološko-naftni Zbornik, 2022
This paper presents the implementation of site-specific analysis in observing the performance of a monumental building in Bengkulu City, Indonesia that is called the Lighthouse View Tower. This building was inaugurated in 2012.
Lindung Zalbuin Mase, Recky Yundrismein, Muhammad Ali Nursalam, Surya Manggala Putra, Aza Shelina, Sahrul Hari Nugroho   +5 more
doaj  

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

CUDA-based parallel acceleration algorithm for wavelet denoising of airborne γ-ray spectrometry data

He jishu
BackgroundThe volume of aviation gamma spectrum data is immense. If only a central processing unit (CPU) is used for data post-processing, it would be constrained by computational efficiency.PurposeThis study aims to propose a CUDA-based graphics ...
XIONG Chao, WANG Xin, WANG Xinjie, WU Hexi   +3 more
doaj   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source