Results 71 to 80 of about 1,208,920 (250)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Advanced Approaches to High Intensity Laser-Driven Ion Acceleration [PDF]

, 2010
Since the pioneering work that was carried out 10 years ago, the generation of highly energetic ion beams from laser-plasma interactions has been investigated in much detail in the regime of target normal sheath acceleration (TNSA). Creation of ion beams
Henig, Andreas
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

A STUDY OF BUILDING PERFORMANCE INSPECTION BASED ON A COMBINATION OF SITE-SPECIFIC RESPONSE ANALYSIS AND STRUCTURAL ANALYSIS (A CASE STUDY OF THE LIGHTHOUSE VIEW TOWER IN BENGKULU CITY, INDONESIA)

Rudarsko-geološko-naftni Zbornik, 2022
This paper presents the implementation of site-specific analysis in observing the performance of a monumental building in Bengkulu City, Indonesia that is called the Lighthouse View Tower. This building was inaugurated in 2012.
Lindung Zalbuin Mase, Recky Yundrismein, Muhammad Ali Nursalam, Surya Manggala Putra, Aza Shelina, Sahrul Hari Nugroho   +5 more
doaj  

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Kernel Density Estimation Based Gaussian and Non-Gaussian Random Vibration Data Induction for High-Speed Train Equipment

IEEE Access, 2020
Because general statistics tolerance is not applicable to the induction of non-Gaussian vibration data and the methods for converting non-Gaussian data into Gaussian data are not always effective and can increase the estimation error, a novel kernel ...
Peng Wang, Hua Deng, Yi Min Wang, Yue Liu, Yi Zhang   +4 more
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Interhemispheric comparison of spectral width boundary as observed by the SuperDARN radars [PDF]

, 2003
International audiencePrevious studies have shown that dayside equatorward edge of coherent HF radar backscatter having broad Doppler spectral width is coincident with the equatorward edge of the cusp particle precipitation.
Milan, S. E., N. Sato, T. Iyemori, T. Iyemori (7616135), Woodfield, E.E., Lester, M., A. S. Yukimatu, A. S. Yukimatu (7614353), M. Lester, N. Sato (7606136), Milan, S.E., M. Lester (7589660), K. Hosokawa, S. E. Milan, Yukimatu, A. S., Iyemori, T., K. Hosokawa (7606139), Hosokawa, K., E. E. Woodfield (7590071), E. E. Woodfield, Sato, N., Yukimatu, A.S., S. E. Milan (7594526), Woodfield, E. E.   +23 more
core   +2 more sources

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source