Results 71 to 80 of about 42,296 (307)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Dizhen xuebao地震动特性受到地震震源、地震波传播介质和局部场地条件等因素的综合影响，虽然地震动反应谱虽然具有统计意义上的共性，但其具体形状又各不相同，特别是部分加速度反应谱与统计平均值之间存在显著的规律性偏差。为了进一步探究加速度反应谱与统计平均值之间的规律性偏差，本文基于日本KiK-net台网获取的8万余条强震动记录，建立了考虑地震震级和震中距影响的地面峰值加速度归一化加速度反应谱，并以预测值＋0.5倍方差为界将加速度反应谱分为有、无反应谱规律性偏差的两组。通过有反应谱规律性偏差的反应谱（观测值 ...
Mingming Yuan, Xiaojun Li, Yushi Wang
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
, 2023 Solar flares are efficient particle accelerators with a large fraction of released magnetic energy (10-50%) converted into energetic particles such as hard X-ray producing electrons.
Natasha L. S. Jeffrey +5 more
core +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
MATEC Web of Conferences, 2018 Spectral acceleration and acceleration time histories are the two seismic loads generally used for dynamic analysis of a building. The structural design of buildings is implemented using spectral acceleration at the ground surface obtained from the ...
Partono Windu +5 more
doaj +1 more source
The evaluation of strengthening effect reinforced concrete structures with FRP on seismic dynamic performance of the structures [PDF]
Journal of Structural and Construction Engineering, 2019 Nowadays, Strengthening of existing structures was conducted by FRP wrapping in Iran in order to increase capacity and ductility particularly for columns resulting in an increase in the strength of concrete and improve structure behaviour. In this study,
Mohammad Kazem Sharbatdar, Hakime Parsa
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Spectral control in proton acceleration with multiple laser pulses
, 2007 We address the question of whether multiple high intensity (> 10(18) W cm(-2)) laser pulses ( each O( 100 fs)) can produce proton beams with a modified energy spectrum on irradiating a foil target.
McKenna, P. +3 more
core +1 more source