Results 61 to 70 of about 64,517 (265)
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
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Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
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An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
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Scientific Reports, 2017 A major challenge in clinical cancer research is the identification of accurate molecular subtype. While unsupervised clustering methods have been applied for class discovery, this clustering method remains a bottleneck in developing accurate method for ...
Mingguang Shi, Guofu Xu
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Sensors, 2022 Hyperspectral imaging can simultaneously acquire spectral and spatial information of the samples and is, therefore, widely applied in the non-destructive detection of grain quality.
Zhen Kang +5 more
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Hierarchical kernel spectral clustering [PDF]
Neural Networks, 2012 Kernel spectral clustering fits in a constrained optimization framework where the primal problem is expressed in terms of high-dimensional feature maps and the dual problem is expressed in terms of kernel evaluations. An eigenvalue problem is solved at the training stage and projections onto the eigenvectors constitute the clustering model.
Alzate Perez, Carlos, Suykens, Johan
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Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
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An Improvement of Spectral Clustering via Message Passing and Density Sensitive Similarity
IEEE Access, 2019 Spectral clustering transforms the data clustering problem into a graph-partitioning problem and classifies data points by finding the optimal sub-graphs. Traditional spectral clustering algorithms use Gaussian kernel function to construct the similarity
Lijuan Wang, Shifei Ding, Hongjie Jia
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Covariate-assisted spectral clustering [PDF]
Biometrika, 2017 28 pages, 4 figures, includes substantial changes to theoretical ...
Norbert Binkiewicz +2 more
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Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
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