Results 51 to 60 of about 114,083 (289)

The Optical System Design of a Space-Based Wide-Field Infrared Slitless Spectrometer

Photonics
With the increasingly complex space environment, the operational safety of spacecraft faces severe challenges, creating an urgent need to develop efficient and reliable space target detection and identification technologies. Traditional optical detection
Yue Chen, Liang Zhou, Peiquan Chen, Pengkai Dong, Haiyang Zhang, Wenji She   +5 more
doaj   +1 more source

Identification of Vehicle System Dynamics from the Aspect of Interaction between the Steering and the Suspension Systems

Machines, 2022
Steering and suspension systems of a motor vehicle have very important mutual connections that have direct influence on a vehicle’s steerability, stability, comfort and life expectancy.
Danijela Miloradović, Jovanka Lukić, Jasna Glišović, Nenad Miloradović   +3 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

HelioSpectrotron 5000: an interactive solar atlas

The Open Journal of Astrophysics
HelioSpectrotron 5000 (HS5000) is an interactive, multi-resolution solar spectral atlas designed to facilitate direct comparison between high-resolution reference spectra and observations obtained with a wide range of ground-based instruments.
Alexander G.M. Pietrow
doaj   +1 more source

Application of the Goertzel’s algorithm in the airgap mixed eccentricity fault detection [PDF]

Serbian Journal of Electrical Engineering, 2015
In this paper, a suitable method for the on-line detection of the airgap mixed eccentricity fault in a three-phase cage induction motor has been proposed.
Reljić Dejan, Tomić Josif, Kanović Željko   +2 more
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

On-line parameter and delay estimation of continuous-time dynamic systems

International Journal of Applied Mathematics and Computer Science, 2015
The problem of on-line identification of non-stationary delay systems is considered. The dynamics of supervised industrial processes are usually modeled by ordinary differential equations.
Kozłowski Janusz, Kowalczuk Zdzisław
doaj   +1 more source