Results 61 to 70 of about 711,060 (330)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

The N Enrichment and Supernova Ejection of the Runaway Microquasar LS 5039 [PDF]

, 2003
We present an investigation of new optical and ultraviolet spectra of the mass donor star in the massive X-ray binary LS 5039. The optical band spectral line strengths indicate that the atmosphere is N-rich and C-poor, and we classify the stellar ...
Brandt N., Claret A., Clausen J. V., Cousins A. W. J., D. R. Gies, D. W. Wingert, De Greve J. P., de Loore C., Dearborn D. S. P., Howarth I. D., Kaper L., Kaper L., Kilkenny D., L. Kaper, Lamers H. J. G. L. M., M. V. McSwain, Mathys G., Meynet G., Nelemans G., P. J. Wiita, Puls J., Ribo M., Schonberner D., Vanbeveren D., W. Huang, Wade R. A., Wellstein S., Zahn J.-P.   +27 more
core   +2 more sources

Line identification in high-resolution, near-infrared CRIRES spectra of chemically peculiar and Herbig Ae stars [PDF]

, 2012
Context. Contrary to the late-type stars, our knowledge of atomic transitions in intermediate-mass stars is still very poor. The recent availability of ESO’s high-resolution spectrograph CRIRES offers now the opportunity to study numerous spectral ...
S. Hubrig, F. Castelli, J. F. González, V. Elkin, G. Mathys, C. Cowley, B. Wolff, M. Schoeller   +7 more
semanticscholar   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

First detection of bromine and antimony in hot stars

, 2018
Bromine (atomic number Z=35) and antimony (Z=51) are extremely difficult to detect in stars. In very few instances, weak and mostly uncertain identifications of Br I, Br II, and Sb II in relatively cool, chemically peculiar stars were successful. Adopted
Knoerzer, M., Kruk, J. W., Rauch, T., Werner, K.   +3 more
core   +1 more source

The XMM-Newton view of Mrk3 and IXO30 [PDF]

, 2005
We present the analysis of the XMM-Newton EPIC pn spectrum of the Seyfert 2 galaxy, Mrk3. We confirm that the source is dominated by a pure Compton reflection component and an iron K$\alpha$ line, both produced as reflection from a Compton-thick torus ...
Anders, Andrew C. Fabian, Awaki, Awaki, Basko, Bearden, Bianchi, Bianchi, Cappi, Colbert, de Vaucouleurs, Dickey, Georgantopoulos, Giovanni Miniutti, Guainazzi, House, Iwasawa, Iwasawa, Kaastra, Kazushi Iwasawa, Kruper, Liedahl, Liedahl, Magdziarz, Matt, Matt, Matt, Miller, Molendi, Morse, Mukai, Ogle, Palmeri, Piconcelli, Porquet, Ptak, Reynolds, Sako, Stefano Bianchi, Strohmayer, Strüder, Tran, Turner, Turner, Verner, Woo, Yaqoob   +46 more
core   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Application of the Goertzel’s algorithm in the airgap mixed eccentricity fault detection [PDF]

Serbian Journal of Electrical Engineering, 2015
In this paper, a suitable method for the on-line detection of the airgap mixed eccentricity fault in a three-phase cage induction motor has been proposed.
Reljić Dejan, Tomić Josif, Kanović Željko   +2 more
doaj   +1 more source

Identification of a New $\gamma$-ray-emitting narrow-line Seyfert 1 Galaxy, at Redshift $\sim1$

, 2015
We report on the identification of a new $\gamma$-ray-emitting narrow-line Seyfert 1 (NLS1) galaxy, SDSS J122222.55+041315.7, which increases the number of known objects of this remarkable but rare type of active galactic nuclei (AGN) to seven.
Komossa, S., Liu, Bifang, Qiao, Erlin, Yao, Su, Yuan, Weimin, Zhang, Jin, Zhou, Hongyan   +6 more
core   +1 more source