Results 61 to 70 of about 114,083 (289)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Molecular Hydrogen Line Identifications in Solar Flares Observed by IRIS: Lower Atmospheric Structure from Radiometric Analysis

The Astrophysical Journal
A rich spectrum of molecular hydrogen (H _2 ) emission lines is seen in sensitive observations from the far-ultraviolet (FUV) channels of the Interface Region Imaging Spectrograph (IRIS) during flare activity in solar active region NOAA Active Region ...
Sarah A. Jaeggli, Adrian N. Daw
doaj   +1 more source

Toward spectrometerless instant Raman identification with tailored metasurfaces-powered guided-mode resonances (GMR) filters

Nanophotonics, 2021
Raman identification is an instrumental tool with a broad range of applications, yet current spectroscopy approaches fall short in facilitating practical and scalable Raman identification platforms.
Mousa Mohamed A., Rafat Nadia H., Saleh Amr A. E.   +2 more
doaj   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Maser Activity of Organic Molecules toward Sgr B2(N)

The Astrophysical Journal
At centimeter wavelengths, single-dish observations have suggested that the Sagittarius (Sgr) B2 molecular cloud at the Galactic Center hosts weak maser emission from several organic molecules, including CH _2 NH, HNCNH, and HCOOCH _3 . However, the lack
Ci Xue, Anthony Remijan, Alexandre Faure, Emmanuel Momjian, Todd R. Hunter, Ryan A. Loomis, Eric Herbst, Brett McGuire   +7 more
doaj   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Revisiting Near-infrared Features of Kilonovae: The Importance of Gadolinium

The Astrophysical Journal
The observation of the kilonova AT2017gfo and investigations of its light curves and spectra confirmed that neutron star mergers are sites of r -process nucleosynthesis.
Salma Rahmouni, Masaomi Tanaka, Nanae Domoto, Daiji Kato, Kenta Hotokezaka, Wako Aoki, Teruyuki Hirano, Takayuki Kotani, Masayuki Kuzuhara, Motohide Tamura   +9 more
doaj   +1 more source

Defect Detection in Arc-Welding Processes by Means of the Line-to-Continuum Method and Feature Selection

Sensors, 2009
Plasma optical spectroscopy is widely employed in on-line welding diagnostics. The determination of the plasma electron temperature, which is typically selected as the output monitoring parameter, implies the identification of the atomic emission lines ...
Olga M. Conde, Adolfo Cobo, P. Beatriz Garcia-Allende, Jesus Mirapeix, Jose M. Lopez-Higuera   +4 more
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Identification and Determination of the Bloodstains Dry Time in the Crime Scenes Using Laser-Induced Breakdown Spectroscopy

IEEE Photonics Journal, 2019
The bloodstain is one kind of the most important evidences in crime scenes. Laser-induced breakdown spectroscopy (LIBS) technology was used in this paper to distinguish bloodstains from analogs and determine the time since deposited (TSD) of bloodstains.
Qianqian Wang, Geer Teng, Yu Zhao, Xutai Cui, Kai Wei   +4 more
doaj   +1 more source