Results 71 to 80 of about 999,597 (267)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

The mechanism of carbon monoxide fluorescence inside a femtosecond laser-induced plasma

Open Physics
The fluorescence spectrum of CO molecules in intense femtosecond laser fields was studied experimentally. Distinct spectral lines from excited atoms and molecules were identified.
Zhang Junfeng, Shi Dandan, Wang Qinxin, Lv Hang   +3 more
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Small-scale magnetic field effects on individual spectral line radial velocities in the photosphere and chromosphere of the Sun

Astronomy & Astrophysics
Context. Advancements in extreme-precision radial velocity (RV) observations for detecting low-mass exoplanets show that different spectral lines show different behaviours in response to stellar activity. Though this can be dealt with experimentally, why
Dorval P., Piskunov N., de la Cruz Rodríguez J.   +2 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Selection of the optimal combination of water vapor absorption lines for detection of temperature in combustion zones of mixing supersonic gas flows by diode laser absorption spectrometry

EPJ Web of Conferences, 2017
Determination of a gas medium temperature by diode laser absorption spectrometry (DLAS) is based on the measurement of integral intensities of the absorption lines of a test molecule (generally water vapor molecule).
Mironenko V.R., Kuritsyn Yu.A., Bolshov M.A., Liger V.V.   +3 more
doaj   +1 more source

Atmospheric transmission coefficients for laser pulses with spectral widths of a few tenths of a nanometer over the wavelength region from 800 to 860 nanometers [PDF]

Effective atmospheric transmission spectra were calculated from 800 to 860 nanometers for laser sources with spectral widths of a few tenths of a nanometer.
Safren, H. G.
core   +1 more source

A Spectral Line Survey from 138.3 to 150.7 GHZ toward Orion-KL

, 2000
We present the results of a spectral line survey from 138.3 to 150.7 GHz toward Orion-KL. The observations were made using the 14 m radio telescope of Taeduk Radio Astronomy Observatory.
Bauder A., Chang Won Lee, Greaves J. S., Johansson L. E. B., Lee C. W., Lovas F. J., Park Y. S., Se‐Hyung Cho, Sung‐Min Lee, Xu L.-H.   +9 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source