Results 31 to 40 of about 25,119 (232)
Nature Communications, 2020 The cell cortex that supports the plasma membrane contains spectrin, a protein that interacts with the acto-myosin cytoskeleton. Here, the authors analyze spectrin behavior during cellular mechanoresponse and membrane trafficking, and observe spectrin ...
Andrea Ghisleni +8 more
doaj +1 more source
, 2014 Beta III spectrin is present throughout the elaborate dendritic tree of cerebellar Purkinje cells and is required for normal neuronal morphology and cell survival.
Perkins, Emma M. +6 more
core +1 more source
Spherocytosis-Related L1340P Mutation in Ankyrin Affects Its Interactions with Spectrin
Life, 2023 Previously, we reported a new missense mutation in the ANK1 gene that correlated with the hereditary spherocytosis phenotype. This mutation, resulting in L1340P substitution (HGMD CM149731), likely leads to the changes in the conformation of the ankyrin ...
Beata Machnicka +4 more
doaj +1 more source
The Design and Preparation of a Model Spectrin Protein: βII-Spectrin L2079P
, 2010 Spectrin isoforms are cytoskeletal proteins that give stability to cells. Site directed mutagenesis was used to replace residue 2079 in brain spectrin βII from leucine to proline, the corresponding amino acid in red blood cell spectrin βI.
Fung, L.W.M., Antoniou, A., Palmer, N.
core +2 more sources
BMC Microbiology, 2012 Background The spectrin cytoskeleton is emerging as an important host cell target of enteric bacterial pathogens. Recent studies have identified a crucial role for spectrin and its associated proteins during key pathogenic processes of Listeria ...
Ruetz Tyson J +2 more
doaj +1 more source
Identifying the Phenotypes of Diffuse Axonal Injury Following Traumatic Brain Injury
Brain Sciences, 2023 Diffuse axonal injury (DAI) is a significant feature of traumatic brain injury (TBI) across all injury severities and is driven by the primary mechanical insult and secondary biochemical injury phases.
Justin L. Krieg +3 more
doaj +1 more source
Spectrin and Other Membrane-Skeletal Components in Human Red Blood Cells of Different Age
Cellular Physiology and Biochemistry, 2017 Background: Old human red blood cells (RBCs) have a reduced surface area with respect to young RBCs. If this decrease occurred through the release of vesicles similar to the spectrin-free vesicles that are shed in vitro under different experimental ...
Annarita Ciana +2 more
doaj +1 more source
Regulation of Cardiac Conduction and Arrhythmias by Ankyrin/Spectrin-Based Macromolecular Complexes
Journal of Cardiovascular Development and Disease, 2021 The cardiac conduction system is an extended network of excitable tissue tasked with generation and propagation of electrical impulses to signal coordinated contraction of the heart.
Drew Nassal +6 more
doaj +1 more source
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2005 Several isoforms of spectrin membrane skeleton proteins have been localized to the Golgi complex. Golgi-specific membrane skeleton proteins associate with the Golgi as a detergent-resistant cytoskeletal structure that likely undergoes a dynamic assembly process that accommodates Golgi membrane dynamics.
openaire +2 more sources
Advanced Science, EarlyView.In response to hypertrophic stimuli, increased c‑JUN phosphorylation upregulates RNF115, leading to SPTBN1 ubiquitination and degradation. which promotes F‑actin depolymerization and YAP activation, driving cardiac hypertrophy. The RNF115 inhibitor DTD effectively suppresses SPTBN1 ubiquitination and cardiac hypertrophy.
Yan Zu +12 more
wiley +1 more source