Results 21 to 30 of about 21,361 (186)
Identifying the Phenotypes of Diffuse Axonal Injury Following Traumatic Brain Injury
Brain Sciences, 2023 Diffuse axonal injury (DAI) is a significant feature of traumatic brain injury (TBI) across all injury severities and is driven by the primary mechanical insult and secondary biochemical injury phases.
Justin L. Krieg +3 more
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EzrA: a spectrin-like scaffold in the bacterial cell division machinery
Microbial Cell, 2015 Much progress has been made in identifying the components of the divisome, the assembly of proteins that undertakes the vital process of cell division in bacteria.
Robert M Cleverley, Richard J Lewis
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Regulation of Cardiac Conduction and Arrhythmias by Ankyrin/Spectrin-Based Macromolecular Complexes
Journal of Cardiovascular Development and Disease, 2021 The cardiac conduction system is an extended network of excitable tissue tasked with generation and propagation of electrical impulses to signal coordinated contraction of the heart.
Drew Nassal +6 more
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Spectrin-based membrane skeleton supports ciliogenesis.
PLoS Biology, 2019 Cilia are remarkable cellular devices that power cell motility and transduce extracellular signals. To assemble a cilium, a cylindrical array of 9 doublet microtubules push out an extension of the plasma membrane.
Ru Jia +12 more
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β-spectrinBari: a truncated β-chain responsible for dominant hereditary spherocytosis
Haematologica, 2009 We describe a β-spectrin variant, named β-spectrin Bari, characterized by a truncated chain and associated with hereditary spherocytosis. The clinical phenotype consists of a moderately severe hemolytic anemia, splenomegaly, and spherocytes and ...
Silverio Perrotta +10 more
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Cancer Medicine, 2023 Background Tumor‐associated angiogenesis mediates the growth and metastasis of most solid cancers. Targeted therapies of the VEGF pathways can effectively block these processes but often fail to provide lasting benefits due to acquired resistance and ...
Eun‐A. Kwak +6 more
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Nature Communications, 2020 The cell cortex that supports the plasma membrane contains spectrin, a protein that interacts with the acto-myosin cytoskeleton. Here, the authors analyze spectrin behavior during cellular mechanoresponse and membrane trafficking, and observe spectrin ...
Andrea Ghisleni +8 more
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Spectrin and Other Membrane-Skeletal Components in Human Red Blood Cells of Different Age
Cellular Physiology and Biochemistry, 2017 Background: Old human red blood cells (RBCs) have a reduced surface area with respect to young RBCs. If this decrease occurred through the release of vesicles similar to the spectrin-free vesicles that are shed in vitro under different experimental ...
Annarita Ciana +2 more
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American Journal of Clinical Pathology, 2011 Abstract Spectrins are large, rod-like, multifunctional molecules that participate in maintaining cell structure, signal transmission, and DNA repair. Because little is known about the role of spectrins in normal hematopoiesis and leukemogenesis, we immunohistochemically stained bone marrow biopsy specimens from 81 patients for αI, αII ...
Lucia R. Wolgast +10 more
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BMC Microbiology, 2012 Background The spectrin cytoskeleton is emerging as an important host cell target of enteric bacterial pathogens. Recent studies have identified a crucial role for spectrin and its associated proteins during key pathogenic processes of Listeria ...
Ruetz Tyson J +2 more
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