Results 11 to 20 of about 25,119 (232)
Spectrin-based membrane skeleton supports ciliogenesis.
PLoS Biology, 2019 Cilia are remarkable cellular devices that power cell motility and transduce extracellular signals. To assemble a cilium, a cylindrical array of 9 doublet microtubules push out an extension of the plasma membrane.
Ru Jia +12 more
doaj +2 more sources
American Journal of Clinical Pathology, 2011 Abstract Spectrins are large, rod-like, multifunctional molecules that participate in maintaining cell structure, signal transmission, and DNA repair. Because little is known about the role of spectrins in normal hematopoiesis and leukemogenesis, we immunohistochemically stained bone marrow biopsy specimens from 81 patients for αI, αII ...
Lucia R. Wolgast +10 more
openaire +2 more sources
Spectrin functions upstream of ankyrin in a spectrin cytoskeleton assembly pathway [PDF]
The Journal of Cell Biology, 2006 Prevailing models place spectrin downstream of ankyrin in a pathway of assembly and function in polarized cells. We used a transgene rescue strategy in Drosophila melanogaster to test contributions of four specific functional sites in β spectrin to its assembly and function.
Das, Amlan +3 more
openaire +3 more sources
Calmodulin binding to human spectrin [PDF]
FEBS Letters, 1984 Calmodulin is shown to interact with human spectrin dimer. The binding was highly calcium‐dependent and observed in two different kinds of experiments. Firstly, affinity chromatography of calmodulin on a Sepharose 4B column with immobilized spectrin, and secondly, partition in aqueous two‐phase polymer systems.
Berglund, Åsa +2 more
openaire +3 more sources
AU-Neurophysics-Lab/Spectrin-Axonal-Mobility-Model: Spectrin Axonal Transport Model
, 2023 This release is the initial version of the spectrin axonal transport ...
AU-Neurophysics-Lab
core +1 more source
αI-spectrin represents evolutionary optimization of spectrin for red blood cell deformability [PDF]
, 2021 Spectrin tetramers of the membranes of enucleated mammalian erythrocytes play a critical role in red blood cell survival in circulation. One of the spectrins, αI, emerged in mammals with enucleated red cells following duplication of the ancestral α ...
Hillyer, Christopher D. +9 more
core +1 more source
β-III-spectrin N-terminus is required for high-affinity actin binding and SCA5 neurotoxicity
Scientific Reports, 2022 Recent structural studies of β-III-spectrin and related cytoskeletal proteins revealed N-terminal sequences that directly bind actin. These sequences are variable in structure, and immediately precede a conserved actin-binding domain composed of tandem ...
Sarah A. Denha +3 more
doaj +1 more source
Long noncoding RNA regulation of spermatogenesis via the spectrin cytoskeleton in Drosophila
G3: Genes, Genomes, Genetics, 2021 The spectrin cytoskeleton has been shown to be critical in diverse processes such as axon development and degeneration, myoblast fusion, and spermatogenesis.
Mark J Bouska, Hua Bai
doaj +1 more source
Mena/VASP and αII-Spectrin complexes regulate cytoplasmic actin networks in cardiomyocytes and protect from conduction abnormalities and dilated cardiomyopathy [PDF]
, 2013 BACKGROUND: In the heart, cytoplasmic actin networks are thought to have important roles in mechanical support, myofibrillogenesis, and ion channel function.
Benz, PM +35 more
core +1 more source