Results 11 to 20 of about 21,361 (186)
αII-spectrin in T cells is involved in the regulation of cell-cell contact leading to immunological synapse formation? [PDF]
PLoS ONE, 2017 T-lymphocyte activation after antigen presentation to the T-Cell Receptor (TCR) is a critical step in the development of proper immune responses to infection and inflammation.
Justyna M Meissner +8 more
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β-III-spectrin N-terminus is required for high-affinity actin binding and SCA5 neurotoxicity
Scientific Reports, 2022 Recent structural studies of β-III-spectrin and related cytoskeletal proteins revealed N-terminal sequences that directly bind actin. These sequences are variable in structure, and immediately precede a conserved actin-binding domain composed of tandem ...
Sarah A. Denha +3 more
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Long noncoding RNA regulation of spermatogenesis via the spectrin cytoskeleton in Drosophila
G3: Genes, Genomes, Genetics, 2021 The spectrin cytoskeleton has been shown to be critical in diverse processes such as axon development and degeneration, myoblast fusion, and spermatogenesis.
Mark J Bouska, Hua Bai
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Erythroid and nonerythroid spectrins [PDF]
Blood, 1993 Abstract Recent developments have contributed important information to understanding the role of spectrins in the RBC membrane skeleton and nonerythroid cells. Many questions can now be framed, informed by structural knowledge of various spectrin subunit types and alternatively spliced variants, that previously could not have been ...
J C, Winkelmann, B G, Forget
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The Physiological Molecular Shape of Spectrin: A Compact Supercoil Resembling a Chinese Finger Trap. [PDF]
PLoS Computational Biology, 2015 The primary, secondary, and tertiary structures of spectrin are reasonably well defined, but the structural basis for the known dramatic molecular shape change, whereby the molecular length can increase three-fold, is not understood.
Jeffrey W Brown +5 more
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Spectrin functions upstream of ankyrin in a spectrin cytoskeleton assembly pathway [PDF]
The Journal of Cell Biology, 2006 Prevailing models place spectrin downstream of ankyrin in a pathway of assembly and function in polarized cells. We used a transgene rescue strategy in Drosophila melanogaster to test contributions of four specific functional sites in β spectrin to its assembly and function.
Das, Amlan +3 more
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Brazilian Journal of Medical and Biological Research, 2002 Hereditary spherocytosis (HS) is a common inherited anemia characterized by the presence of spherocytic red cells. Defects in several membrane protein genes have been involved in the pathogenesis of HS. ß-Spectrin-related HS seems to be common. We report
D.S. Bassères +3 more
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Spherocytosis-Related L1340P Mutation in Ankyrin Affects Its Interactions with Spectrin
Life, 2023 Previously, we reported a new missense mutation in the ANK1 gene that correlated with the hereditary spherocytosis phenotype. This mutation, resulting in L1340P substitution (HGMD CM149731), likely leads to the changes in the conformation of the ankyrin ...
Beata Machnicka +4 more
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Memorias do Instituto Oswaldo Cruz, 2000 The invasion of the erythrocyte by Plasmodium falciparum depends on the ability of the merozoite to move through the membrane invagination. This ability is probably mediated by actin dependent motors.
Claudia Forero, Moisés Wasserman
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The actin binding domain of βI-spectrin regulates the morphological and functional dynamics of dendritic spines. [PDF]
PLoS ONE, 2011 Actin microfilaments regulate the size, shape and mobility of dendritic spines and are in turn regulated by actin binding proteins and small GTPases. The βI isoform of spectrin, a protein that links the actin cytoskeleton to membrane proteins, is present
Michael W Nestor +4 more
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