Results 41 to 50 of about 51,266 (290)
Erythroid and nonerythroid spectrins [PDF]
Blood, 1993 Abstract Recent developments have contributed important information to understanding the role of spectrins in the RBC membrane skeleton and nonerythroid cells. Many questions can now be framed, informed by structural knowledge of various spectrin subunit types and alternatively spliced variants, that previously could not have been ...
J C, Winkelmann, B G, Forget
openaire +3 more sources
β-spectrinBari: a truncated β-chain responsible for dominant hereditary spherocytosis
Haematologica, 2009 We describe a β-spectrin variant, named β-spectrin Bari, characterized by a truncated chain and associated with hereditary spherocytosis. The clinical phenotype consists of a moderately severe hemolytic anemia, splenomegaly, and spherocytes and ...
Silverio Perrotta +10 more
doaj +1 more source
Disruption of spectrin-like cytoskeleton in differentiating keratinocytes by PKCδ activation is associated with phosphorylated adducin. [PDF]
PLoS ONE, 2011 Spectrin is a central component of the cytoskeletal protein network in a variety of erythroid and non-erythroid cells. In keratinocytes, this protein has been shown to be pericytoplasmic and plasma membrane associated, but its characteristics and ...
Kong-Nan Zhao +2 more
doaj +1 more source
Control of erythroid differentiation: asynchronous expression of the anion transporter and the peripheral components of the membrane skeleton in AEV- and S13-transformed cells [PDF]
, 1986 Chicken erythroblasts transformed with avian erythroblastosis virus or S13 virus provide suitable model systems with which to analyze the maturation of immature erythroblasts into erythrocytes.
Boyer, Brigitte +3 more
core +1 more source
Brazilian Journal of Medical and Biological Research, 2002 Hereditary spherocytosis (HS) is a common inherited anemia characterized by the presence of spherocytic red cells. Defects in several membrane protein genes have been involved in the pathogenesis of HS. ß-Spectrin-related HS seems to be common. We report
D.S. Bassères +3 more
doaj +1 more source
The actin binding domain of βI-spectrin regulates the morphological and functional dynamics of dendritic spines. [PDF]
PLoS ONE, 2011 Actin microfilaments regulate the size, shape and mobility of dendritic spines and are in turn regulated by actin binding proteins and small GTPases. The βI isoform of spectrin, a protein that links the actin cytoskeleton to membrane proteins, is present
Michael W Nestor +4 more
doaj +1 more source
Spherocytosis-Related L1340P Mutation in Ankyrin Affects Its Interactions with Spectrin
Life, 2023 Previously, we reported a new missense mutation in the ANK1 gene that correlated with the hereditary spherocytosis phenotype. This mutation, resulting in L1340P substitution (HGMD CM149731), likely leads to the changes in the conformation of the ankyrin ...
Beata Machnicka +4 more
doaj +1 more source
Spectrins in Axonal Cytoskeletons: Dynamics Revealed by Extensions and Fluctuations [PDF]
, 2014 The macroscopic properties, the properties of individual components and how those components interact with each other are three important aspects of a composited structure.
Carmo M. +3 more
core +1 more source
Memorias do Instituto Oswaldo Cruz, 2000 The invasion of the erythrocyte by Plasmodium falciparum depends on the ability of the merozoite to move through the membrane invagination. This ability is probably mediated by actin dependent motors.
Claudia Forero, Moisés Wasserman
doaj +1 more source
Nature Communications, 2020 The cell cortex that supports the plasma membrane contains spectrin, a protein that interacts with the acto-myosin cytoskeleton. Here, the authors analyze spectrin behavior during cellular mechanoresponse and membrane trafficking, and observe spectrin ...
Andrea Ghisleni +8 more
doaj +1 more source