Results 71 to 80 of about 51,266 (290)

αII Spectrin Forms a Periodic Cytoskeleton at the Axon Initial Segment and Is Required for Nervous System Function

Journal of Neuroscience, 2017
Spectrins form a submembranous cytoskeleton proposed to confer strength and flexibility to neurons and to participate in ion channel clustering at axon initial segments (AIS) and nodes of Ranvier.
C. Huang, Chuansheng Zhang, T. Ho, J. Oses-Prieto, A. Burlingame, Joshua Lalonde, J. Noebels, Christophe Leterrier, M. Rasband   +8 more
semanticscholar   +1 more source

Non‐Synaptic Function and Localization of Syntaxin‐Binding Protein 1 in a Mouse Model of STXBP1‐Related Epileptic Encephalopathy

Annals of Neurology, EarlyView.
Objective De novo mutations in the syntaxin‐binding protein 1 (STXBP1), encoded by STXBP1, are among the most prevalent causes of variable neurodevelopmental disorders, including epileptic encephalopathy, developmental delay, and movement disorders.
Tao Yang, Rajat Banerjee, Yamei Deng, Sheetal Jahagirdar1, Alexey I. Nesvizhskii, Michael D. Uhler, Jack M. Parent, Yu Wang   +7 more
wiley   +1 more source

Severe hereditary spherocytosis presenting with non-immune fetal hydrops

Indian Pediatrics Case Reports, 2023
Background: Hereditary spherocytosis (HS) is characterized by spherocytes on the peripheral smear and heterogeneous clinical presentation (mild, moderate, moderate/severe, and severe) depending upon the severity of hemolytic anemia, jaundice, and ...
Snehal Mallakmir, Rashid Merchant, Nandkishor S Kabra, Javed Ahmed   +3 more
doaj   +1 more source

&bgr;IV-Spectrin regulates STAT3 targeting to tune cardiac response to pressure overload

Journal of Clinical Investigation, 2018
Heart failure (HF) remains a major source of morbidity and mortality in the US. The multifunctional Ca2+/calmodulin-dependent kinase II (CaMKII) has emerged as a critical regulator of cardiac hypertrophy and failure, although the mechanisms remain ...
Sathya D. Unudurthi, D. Nassal, Amara D. Greer-Short, Nehal J. Patel, Taylor Howard, Xianyao Xu, Birce Onal, Tony Satroplus, Deborah Hong, Cemantha Lane, Alyssa Dalic, S. Koenig, Adam C. Lehnig, L. Baer, H. Musa, K. Stanford, Sakima A Smith, P. Mohler, T. Hund   +18 more
semanticscholar   +1 more source

Mitochondria and the Actin Cytoskeleton in Neurodegeneration

Cytoskeleton, EarlyView.
ABSTRACT Mitochondrial dysfunction and cytoskeletal disorganization are widely recognized hallmarks of neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS).
Shivani Tuli, Preet Patel, Aneri Shethji, David Gau   +3 more
wiley   +1 more source

The crystal structures of dystrophin and utrophin spectrin repeats: implications for domain boundaries.

PLoS ONE, 2012
Dystrophin and utrophin link the F-actin cytoskeleton to the cell membrane via an associated glycoprotein complex. This functionality results from their domain organization having an N-terminal actin-binding domain followed by multiple spectrin-repeat ...
Muralidharan Muthu, Kylie A Richardson, Andrew J Sutherland-Smith   +2 more
doaj   +1 more source

Deficiency of αII-spectrin affects endothelial cell–matrix contact and migration leading to impairment of angiogenesis in vitro

Cellular & Molecular Biology Letters, 2020
Background Precise coordination of cytoskeletal components and dynamic control of cell adhesion and migration are required for crucial cell processes such as differentiation and morphogenesis.
Beata Machnicka, Aurélie Ponceau, Julien Picot, Yves Colin, Marie-Christine Lecomte   +4 more
doaj   +1 more source

Effects of embryonic cadmium exposure on erythrocyte indices and morphology in newly hatched Gallus gallus domesticus chicks

Poultry Science, 2022
: The aim of the current study was to assess the influence of embryonic exposure to cadmium on basic and derived erythrocyte indices, the morphology and morphometric properties of erythrocytes, as well as erythrocyte spectrin distribution in newly ...
Bartosz Bojarski, Maria Chmurska-Gąsowska, Anna Gałuszka, Anna Kozłowska, Małgorzata Kotula-Balak, Magdalena Trela, Alena Kirpaniova, Kamil Kustra, Bartłomiej Stonawski, Stanisław Łapiński, Zbigniew Arent, Marcin W. Lis   +11 more
doaj   +1 more source

An αII Spectrin-Based Cytoskeleton Protects Large-Diameter Myelinated Axons from Degeneration

Journal of Neuroscience, 2017
Axons must withstand mechanical forces, including tension, torsion, and compression. Spectrins and actin form a periodic cytoskeleton proposed to protect axons against these forces.
C. Huang, Chuansheng Zhang, D. Zollinger, Christophe Leterrier, M. Rasband   +4 more
semanticscholar   +1 more source

Beta spectrin bestows protein 4.1 sensitivity on spectrin-actin interactions. [PDF]

The Journal of cell biology, 1987
The ability of protein 4.1 to stimulate the binding of spectrin to F-actin has been compared by cosedimentation analysis for three avian (erythrocyte, brain, and brush border) and two mammalian (erythrocyte and brain) spectrin isoforms. Human erythroid protein 4.1 stimulated actin binding of all spectrins except the brush border isoform (TW 260/240 ...
T R, Coleman, A S, Harris, S M, Mische, M S, Mooseker, J S, Morrow   +4 more
openaire   +2 more sources