Results 71 to 80 of about 42,373 (249)

In‐depth analysis of osmotic gradient ektacytometry parameters across different genotypes in hereditary spherocytosis

British Journal of Haematology, EarlyView.
Summary Hereditary spherocytosis (HS) is a hereditary haemolytic anaemia, caused by pathogenic variants in genes encoding red blood cell membrane proteins. Osmotic gradient ektacytometry evaluates red cell deformability and hydration and is increasingly used in the diagnosis of HS.
Jonathan R. A. de Wilde, Geoffrey Z. L. Kuppens, Maryse E. Boesveld, Annelies J. van Vuren, Wouter W. van Solinge, Esmé Waanders, Eduard J. van Beers, Minke A. E. Rab, Marije Bartels, Richard van Wijk   +9 more
wiley   +1 more source

Mechanical characterization of spectrin at the molecular level

Scientific Reports
Spectrin, a large cytoskeletal protein, consists of a heterodimeric structure comprising α and β subunits. Here, we have studied the mechanics of spectrin filament as a major constituent of dendrites and dendritic spines.
Md Nahian Bin Hossain, Ashfaq Adnan
doaj   +1 more source

Common Hematologic Emergencies—Acute Promyelocytic Leukemia and Microangiopathic Hemolytic Anemias—A Pivotal Role of Clinical Laboratory

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Hematologic emergencies are urgent health conditions which result in significant mortality and morbidity unless timely therapeutic measures are taken. Therapeutic success depends on their timely and accurate recognition by hematology laboratory services.
Ganna Shestakova, Nicolas Ulrich Edgar, Anton V. Rets   +2 more
wiley   +1 more source

Dysfunction in the βII Spectrin-Dependent Cytoskeleton Underlies Human Arrhythmia. [PDF]

, 2015
Background: The cardiac cytoskeleton plays key roles in maintaining myocyte structural integrity in health and disease. In fact, human mutations in cardiac cytoskeletal elements are tightly linked with cardiac pathologies including myopathies ...
Bhakta, Deepak, Binkley, Philip F., Bonilla, Ingrid M., Carnes, Cynthia A., Curran, Jerry, Dobrev, Dobromir, Higgins, Robert S., Hughes, Langston D., Hund, Thomas J., Janssen, Paul M., Kilic, Ahmet, Kline, Crystal F., Little, Sean C., Long, Victor P., Ma, Jianjie, Makara, Michael, Mohler, Peter J., Polina, Iuliia, Rasband, Matthew N., Smith, Sakima A., Spoonamore, Katherine G., Sturm, Amy C., Sun, Mingzhai, Vatta, Matteo, Voigt, Niels, Webb, Tyler R., Wei, Zhiyi, Weiss, Raul, Wright, Patrick, Zhang, Chuansheng, Zhang, Mingjie   +30 more
core   +1 more source

Erythrocyte ‘Feierzeit’ reaction: Novel filamentous and vesicular response to n‐butyl acetate

Journal of Microscopy, EarlyView.
Abstract Human erythrocytes (red blood cells; RBCs) undergo spontaneous disassembly after several hours of exposure to n‐butyl acetate (nBA). Images of the morphological changes were captured in time‐lapse sequences using differential interference contrast (DIC) light microscopy.
Philip W. Kuchel
wiley   +1 more source

Axonal Spectrins: Nanoscale Organization, Functional Domains and Spectrinopathies

Frontiers in Cellular Neuroscience, 2019
Spectrin cytoskeletons are found in all metazoan cells, and their physical interactions between actin and ankyrins establish a meshwork that provides cellular structural integrity.
Cheng-Hsin Liu, Matthew Neil Rasband, Matthew Neil Rasband   +2 more
doaj   +1 more source

A T-lymphoma transmembrane glycoprotein (gp180) is linked to the cytoskeletal protein, fodrin. [PDF]

, 1985
A major mouse T-lymphoma surface glycoprotein (gp180) has been identified by labeling cells with 125I and [3H]glucosamine. After ligand-induced receptor patching and/or capping, the amount of gp 180 in the membrane-associated cytoskeleton fraction ...
Bourguignon, LY, Glenney, JR, Nagpal, ML, Suchard, SJ   +3 more
core  

The flat phase of fixed-connectivity membranes [PDF]

, 1996
The statistical mechanics of flexible two-dimensional surfaces (membranes) appears in a wide variety of physical settings. In this talk we discuss the simplest case of fixed-connectivity surfaces.
Aronovitz, Aronovitz, Baig, Chianelli, David, David, Espriu, G. Thorleifsson, Guitter, Guitter, Hwa, K. Anagnostopoulos, Le Doussal, M. Falcioni, M.J. Bowick, Nelson, Phillips, Polyakov, S.M. Catterall, Schmidt, Sokal, Wen, Wheater   +22 more
core   +3 more sources

Erythrokeratodermia‐Cardiomyopathy Syndrome: Expanding the DSP Mutational Spectrum Beyond Proline Substitutions

Pediatric Dermatology, EarlyView.
ABSTRACT Erythrokeratodermia cardiomyopathy (EKC) syndrome is a rare autosomal dominant disorder characterized by generalized erythrokeratoderma and progressive dilated cardiomyopathy, caused by pathogenic variants in the SR6 domain of desmoplakin (DSP).
Sepideh Hamzehlou, Ryland D. Mortlock, Caroline Echeandia‐Francis, Jing Zhou, Chao Xing, Nnenna G. Agim, Keith A. Choate, Donald A. Glass II   +7 more
wiley   +1 more source

Loss of Expression of Human Spectrin Src Homology Domain Binding Protein 1 is Associated with 10p Loss in Human Prostatic Adenocarcinoma

Neoplasia: An International Journal for Oncology Research, 2001
The gene encoding human spectrin Src homology domain binding protein 1, or Hssh3bpl, which is a marker of macropinocytic vesicles and a potential regulator of macropinocytosis, co-localizes to a YAC containing chromosome 10p sequences at loci D10S89 and ...
Jill A. Macoska, Jiliu Xu, Dorota Ziemnicka, Tracy S. Schwab, Mark A. Rubin, Leszek Kotula   +5 more
doaj   +1 more source