Results 151 to 160 of about 198,485 (311)

The Critical Role of Fractionated Urine Glycosaminoglycans in the Evaluation of Mucopolysaccharidosis Type II in Four Unrelated Families

open access: yesAmerican Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Since 2015, Ann and Robert H. Lurie Children's Hospital has performed diagnostic testing for infants who screen positive for mucopolysaccharidosis type II (MPS II) on the Illinois newborn screen. Preliminary diagnostic testing includes measurement of plasma iduronate‐2‐sulfatase enzyme activity and urinary glycosaminoglycan analysis, followed ...
Carly A. Rasmussen   +5 more
wiley   +1 more source

Geometric Nonuniformity Localizes Valence Orbitals in Gold Clusters: Case Study on [Au23(SC6H11)16]–

open access: yesAngewandte Chemie, EarlyView.
The electronic structure of [Au23(SC6H11)16]–, a monolayer‐protected gold cluster with a nonuniform Au13 core, was investigated. Anion photoelectron spectroscopy and density functional theory calculations revealed that the highest occupied molecular orbital (HOMO) and HOMO‐1 are localized on the two triangular Au3 units at the ends of the Au13 core ...
Yosuke Asami   +3 more
wiley   +2 more sources

Quantitative proteomics identifies clusterin as a novel biomarker for atherosclerosis

open access: yesAnimal Models and Experimental Medicine, EarlyView.
This schematic illustrates the proposed mechanism. In advanced atherosclerotic lesions, upregulated CLU on the cell surface activates low‐density lipoprotein (LDL) receptor‐related protein 1 (LRP1). This interaction triggers the phosphorylation and activation of AKT.
Dengfeng Ding   +10 more
wiley   +1 more source

Reduced Symmetry Metal–Organic Cage‐to‐Framework Materials

open access: yesAngewandte Chemie, EarlyView.
A series of Ag(I) MOFs was synthesised from organic cages of varying structure and symmetry as linkers. Minor variations in the cage linkers were shown to significantly influence the structures of the resulting MOFs. This work represents the first incorporation of reduced symmetry (including chiral), intrinsically porous building blocks into MOFs, and ...
Cameron J. T. Cox   +5 more
wiley   +2 more sources

Mechanistic investigation of Liujing Toutong tablet in the treatment of cerebral ischemia–reperfusion injury in rats by the integration of serum pharmacochemistry and metabolomics

open access: yesAnimal Models and Experimental Medicine, EarlyView.
The research strategy for pharmacodynamics, serum pharmacochemistry, metabolomics, and network pharmacology analysis method in intervention effects of LTT are illustrated. Abstract Background Liujing Toutong tablet (LTT) is a traditional Chinese patent medicine.
Zihan Yu   +10 more
wiley   +1 more source

A Mononuclear Ruthenium(V)‐Imido Complex With Hydrogen Bonding in the Second Coordination Sphere Forming Aziridines Without N‐Substituents From Alkenes in Water

open access: yesAngewandte Chemie, EarlyView.
This study employs a RuV═NH complex with hydrogen‐bonding (HB) sites in the SCS to afford non‐N‐substituted aziridines selectively. Nitrogen‐atom transfer occurs from the RuV═NH complex to alkenes in water to produce aziridine derivatives in high yields.
Tomoya Ishizuka   +7 more
wiley   +2 more sources

Diabetes adversely affects phospholipid profiles in human carotid artery endarterectomy plaques [PDF]

open access: yes, 2018
Darwesh, Malik   +8 more
core   +2 more sources

Liposomal Delivery of L‐2‐Hydroxyglutarate for Targeting Epigenetic Dysregulation in Osteoarthritis

open access: yesAdvanced NanoBiomed Research, EarlyView.
Osteoarthritis involves cartilage degeneration, inflammation, and epigenetic dysregulation. A liposomal formulation of the TET1 inhibitor L‐2‐hydroxyglutarate to overcome rapid joint clearance was developed. The formulation showed good physicochemical properties, reduced inflammatory and catabolic gene expression in chondrocytes, and alleviated ...
Denise Murgia   +10 more
wiley   +1 more source

extractive electrospray ionization mass spectrometry

open access: yes
Citation: 'extractive electrospray ionization mass spectrometry' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.09185 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.
openaire   +1 more source

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