Results 61 to 70 of about 164,512 (299)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Nano-Scale Secondary Ion Mass Spectrometry: A Paradigm Shift in Soil Science

Journal of Spectroscopy
Soils exhibit structural heterogeneity across diverse spatio-temporal scales, yielding myriad of microhabitats, highlighting the need for a nuanced understanding of the intricate interactions within the soil matrix.
Yasir Hanif Mir, Anzhen Qin, Shakeel Mir, Shafeeq Ur Rahman, Mehnaza Mushtaq, Mumtaz A. Ganie, M. H. Chesti, Javid A. Bhat, Zahoor A. Baba, M. Auyoub Bhat, Inayat M. Khan, Rehana Rasool, Aanisa Manzoor Shah, Shazia Sadiq, Syed Mohammed Basheeruddin Asdaq, Mohammad Javed Ansari, Ghulam Yasin   +16 more
doaj   +1 more source

Lipid mapping in human dystrophic muscle by cluster-time-of-flight secondary ion mass spectrometry imaging

Journal of Lipid Research, 2008
Human striated muscle samples, from male control and Duchenne muscular dystrophy-affected children, were subjected to cluster-time-of-flight secondary ion mass spectrometry (cluster-ToF-SIMS) imaging using a 25 keV Bi3+ liquid metal ion gun under static ...
Nora Tahallah, Alain Brunelle, Sabine De La Porte, Olivier Laprévote   +3 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Linking biogenic hydrocarbons to biogenic aerosol in the Borneo rainforest [PDF]

Atmospheric Chemistry and Physics, 2013
Emissions of biogenic volatile organic compounds are though to contribute significantly to secondary organic aerosol formation in the tropics, but understanding these transformation processes has proved difficult, due to the complexity of the chemistry ...
J. F. Hamilton, M. R. Alfarra, N. Robinson, M. W. Ward, A. C. Lewis, G. B. McFiggans, H. Coe, J. D. Allan   +7 more
doaj   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Unlocking the potential of battery technologies through Time-of-Flight Secondary Ion Mass Spectrometry

Science and Technology of Advanced Materials
In response to the evolving demands in energy storage, the review underscores the critical need for ongoing research in battery technology, specifically centred to indispensable role of Time-of-Flight Secondary Ion Mass Spectrometry (TOF-SIMS) which aims
Prince Sharma, Gen Hasegawa, Sihao Xing, Naoaki Kuwata   +3 more
doaj   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

Imaging mass spectrometry of polymeric materials [PDF]

, 2009
Imaging mass spectrometry (MS) is a technique that makes images of molecular distributions at surfaces based on mass spectral information. At a range (typically a raster) of positions, mass spectra are measured from the surface giving a characteristic ...
Klerk, L.A., Massaspectrometrie, Sub Biomol.Mass Spectrometry & Proteom., Biomolecular Mass Spectrometry and Proteomics   +3 more
core  

Spectral characterization of ten cyclic lipids using time-of-flight secondary ion mass spectrometry [PDF]

, 2013
RATIONALE Over the last decade, the high lateral resolution and imaging capabilities of time-of-flight secondary ion mass spectrometry (ToF-SIMS) have increasingly stimulated interest in studying organic molecules in complex environmental materials ...
Siljeström, Sandra,, Sjovall, Peter, Martin Blumenberg, Christine Heim, Thiel, Volker, Volker Thiel, Sjövall, Peter,, Tim Leefmann, Thiel, Volker,, Leefmann, Tim,, Siljestrom, Sandra, Blumenberg, Martin,, Leefmann, Tim, Heim, Christine, Peter Sjövall, Heim, Christine,, Blumenberg, Martin, Sandra Siljeström   +17 more
core   +1 more source