Results 71 to 80 of about 4,620,546 (371)

Encoding terahertz holographic bits with a computer-generated 3D-printed phase plate

Scientific Reports
A sub-terahertz holographic image of a two-dimensional 576-bit data code is produced using a diffractive phase-plate element. The phase plate was designed using a modified Gerchberg-Saxton iterative algorithm to encode a focused image of the data code ...
E. Constable, J. Gospodaric, A. Pimenov
doaj   +1 more source

α-catenin switches between a slip and an asymmetric catch bond with F-actin to cooperatively regulate cell junction fluidity

Nature Communications, 2022
By using laser tweezers, the authors show that a single α-catenin molecule does not resist force on F-actin. However, clustering of multiple molecules and force applied toward F-actin pointed end engage a molecular switch in α-catenin, which unfolds and ...
C. Arbore, M. Sergides, L. Gardini, G. Bianchi, A. V. Kashchuk, I. Pertici, P. Bianco, F. S. Pavone, M. Capitanio   +8 more
doaj   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Highly inclined light sheet allows volumetric super-resolution imaging of efflux pumps distribution in bacterial biofilms

Scientific Reports
Bacterial biofilms are highly complex communities in which isogenic bacteria display different gene expression patterns and organize in a three-dimensional mesh gaining enhanced resistance to biocides.
T. Vignolini, M. Capitanio, C. Caldini, L. Gardini, F. S. Pavone   +4 more
doaj   +1 more source

External-Cavity Quantum Cascade Laser-Based Gas Sensor for Sulfur Hexafluoride Detection

Chemosensors, 2022
The external-cavity quantum cascade laser (ECQCL) is an ideal mid-infrared (MIR) spectral light source for determining large molecular-absorption spectral features with broad transition bands.
Xingyu Pan, Yifan Zhang, Jiayu Zeng, Minghui Zhang, Jingsong Li   +4 more
doaj   +1 more source

In-line NIR spectroscopy for the understanding of polymer-drug interaction during pharmaceutical hot-melt extrusion [PDF]

, 2012
The aim was to evaluate near-infrared spectroscopy for the in-line determination of the drug concentration, the polymer-drug solid-state behaviour and molecular interactions during hot-melt extrusion.
Adriaensens, Peter, Carleer, Robert, De Beer, Thomas, Dierickx, Lien, Quintens, Thomas, Remon, Jean Paul, Saerens, Lien, Vervaet, Chris   +7 more
core   +2 more sources

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Computational conjugate adaptive optics microscopy for longitudinal through-skull imaging of cortical myelin

Nature Communications, 2023
The authors realize longitudinal deep-brain imaging through an intact mouse skull by constructing a high-speed reflection matrix microscope at 1.3 µm wavelength and developing a computational conjugate adaptive optics algorithm eliminating skull ...
Yongwoo Kwon, Jin Hee Hong, Sungsam Kang, Hojun Lee, Yonghyeon Jo, Ki Hean Kim, Seokchan Yoon, Wonshik Choi   +7 more
doaj   +1 more source

Topics in Meson Spectroscopy [PDF]

, 2002
In this mini-review I discuss three topics in meson spectroscopy. The production of heavy quarkonium states, S-wave scattering below 1 GeV, and exotic hybrid meson production. This is not intended to be a comprehensive review, just an overview of several
Abe, Adams, Aubert, Becker, Becker, Bodwin, Choi, Close, Close, Close, Csorna, Davies, Eichten, Furman, Godfrey, Godfrey, Godfrey, Godfrey, Godfrey, Grayer, Gu, Gunter, Kaminski, Kuang, Kwong, Manke, Okamoto, Stephen Godfrey, Suzuki, van Beveren, Voloshin, Voloshin, Voloshin, Voloshin   +33 more
core   +2 more sources

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source