Results 81 to 90 of about 59,071 (305)

On Correlationism and the Philosophy of (Human) Access: Meillassoux and Harman

open access: yesOpen Philosophy, 2020
Speculative Realism (SR) has often been characterised as a heterogeneous group of thinkers, united almost exclusively in their commitment to the critique of what Quentin Meillassoux terms ‘correlationism’ or what Graham Harman calls the ‘philosophy of ...
Young Niki
doaj   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

open access: yesFEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Hyperobjects: Philosophy and Ecology After the End of the World by Timothy Morton [PDF]

open access: yes, 2015
Welling reviews Timothy Morton\u27s book Hyperobjects: Philosophy and Ecology after the End of the World (Minneapolis: U of Minnesota P, 2013)
Welling, Bart H.
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

CLOSE: NEARING THE FUTURE BY MEANS OF SYMBIOGENESIS AND HYPEROBJECTIVITY

open access: yesStudia Universitatis Babeș-Bolyai. Philosophia, 2020
Close: Nearing the Future by Means of Symbiogenesis and Hyperobjectivity. At the beginning of the 21st century we find a call for philosophers to join a new alliance: with artists and architects rather than linguists or physicists.
Ioan-Cristian BOBOESCU
doaj   +1 more source

Concerning Dice and Divinity [PDF]

open access: yes, 2006
Einstein initially objected to the probabilistic aspect of quantum mechanics - the idea that God is playing at dice. Later he changed his ground, and focussed instead on the point that the Copenhagen Interpretation leads to what Einstein saw as the ...
Appleby, D. M.
core   +3 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Growing the Living in the Land: Weird Ecology in Rob Guillory’s Comic Farmhand [PDF]

open access: yesPulse, 2021
Weird tales are rooted in gothic, science and speculative fictions but they also engage real science. Rob Guillory’s comics series Farmhand (2018–ongoing) depicts a discordant relationship between science, perception and ideology through themes related ...
Dona Pursall
doaj  

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

open access: yesMolecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan   +9 more
wiley   +1 more source

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