Results 71 to 80 of about 3,344,898 (288)

Evaluating the Validity and Reliability of the Knowledge, and Practice Questionnaire of Iranian Mothers About the Development of Persian-speaking Children Aged 18 to 36 Months [PDF]

Iranian Rehabilitation Journal, 2023
Objectives: The mother’s knowledge and attitude about the child’s developmental norms can affect their practice and the quality of parent-child interaction.
Zahra Valitabar Kerati, Morteza Farazi, Atieh Ashtari, Fatemeh Jazem, Majid Jannat   +4 more
doaj  

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Awareness of Noise-Induced Hearing Loss Related to Exposure to High-Noise Environments—Case Study: Young Adults 18 to 30 in Greece

Audiology Research
Background: Noise-induced hearing loss (NIHL) is one of the most common types of hearing impairment, even though it is preventable. However, awareness and protective behaviors among young adults remain limited.
Nikolaos Trimmis, Melina Kaparou, Theodoros Tsoukalas, Panagiotis Plotas, Voula Chris Georgopoulos   +4 more
doaj   +1 more source

Evaluating the Word/Non-Word Repetition in Adults With Stuttering Based on Stuttering Severity and Length of Words/Non-Words

Journal of Modern Rehabilitation, 2019
Introduction: Stuttering is a speech disorder examined in many studies on motor speech deficiency in people with stuttering. In the area of language, some studies have also shown that people with stuttering are different from people without stuttering in
Farhad Choopanian, Morteza Farazi, Zahrasadat Qoreishi, Atefeh Rahmati, Gholamreza Ghaedamini, Zahra Ilkhani   +5 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Wavelets for intonation modeling in HMM speech synthesis [PDF]

, 2013
The pitch contour in speech contains information about different linguistic units at several distinct temporal scales. At the finest level, the microprosodic cues are purely segmental in nature, whereas in the coarser time scales, lexical tones, word ...
Suni, Antti Santeri, Alku, Paavo, Vainio, Martti, Suni, Antti, Aalto, Daniel, Raitio, Tuomo   +5 more
core  

End-to-End Optimization of Source Models for Speech and Audio Coding Using a Machine Learning Framework

, 2019
Speech coding is the most commonly used application of speech processing. Accumulated layers of improvements have however made codecs so complex that optimization of individual modules becomes increasingly difficult. This work introduces machine learning
Bäckström, Tom, Tom Bäckström
core   +1 more source

Evaluating a drive-through walk-in model for hearing aid management in the public healthcare sector during COVID-19 in South Africa

Discover Global Society
Background The COVID-19 pandemic significantly disrupted healthcare services globally, prompting the need for innovative solutions. In South Africa, a drive-through/walk-in service model was implemented for ear and hearing aid management within the ...
Mubina Khan, Katijah Khoza-Shangase, Sadna Balton   +2 more
doaj   +1 more source