Results 81 to 90 of about 3,344,898 (288)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Speaker adaptation and the evaluation of speaker similarity in the EMIME speech-to-speech translation project [PDF]

, 2010
This paper provides an overview of speaker adaptation research carried out in the EMIME speech-to-speech translation (S2ST) project. We focus on how speaker adaptation transforms can be learned from speech in one language and applied to the acoustic ...
Tokuda, Keiichi, Shannon, Matt, Shiota, Sayaka, Wester, Mirjam; id_orcid, Oura, Keiichiro, Gibson, Matthew, Hirsimaki, Teemu, Yamagishi, Junichi, King, Simon; id_orcid, Karhila, Reima, Wu, Yi-Jian, Tian, Jilei, Dines, John, Byrne, William, Saheer, Lakshmi, Liang, Hui, Kurimo, Mikko, Garner, Philip N., Guan, Yong, King, Simon, Wester, Mirjam   +20 more
core   +1 more source

Affordable web-based foot–ankle exercise program proves effective for diabetic foot care in a randomized controlled trial with economic evaluation

Scientific Reports
The aim of this study was to shed light on a crucial issue through a comprehensive evaluation of the cost-effectiveness and cost-utility of a cutting-edge web-based foot–ankle therapeutic exercise program (SOPeD) designed for treating modifiable risk ...
Ronaldo H. Cruvinel-Júnior, Jane S. S. P. Ferreira, Jady L. Veríssimo, Renan L. Monteiro, Érica Q. Silva, Eneida Y. Suda, Isabel C. N. Sacco   +6 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

The effectiveness of traditional methods and altered auditory feedback in improving speech rate and intelligibility in speakers with Parkinson's disease [PDF]

, 2010
Communication problems are a frequent symptom for people with Parkinson's disease (PD) which can have a significant impact on their quality-of-life. Deciding on the right management approach can be problematic though, as, with the exception of LSVT (R ...
Kröger, Bernd J., Bernd Kröger, Lowit, Anja, Anja Lowit, Howell, Peter, Corinne Dobinson, Claire Timmins, Dobinson, Corinne, Peter Howell, Timmins, Claire, Kröger, Bernd   +10 more
core   +1 more source

Assessment of Female Pelvic Floor Muscles: An Integrative Review

International Journal of Women's Health
Laís Bertoldo Frazão, Leticia Assis Couto, Ana Carolina Atanes Mendes Peres, Amélia Pasqual Marques,* Anice de Campos Pássaro* Physical Therapy, Speech and Occupational Therapy Department, School of Medicine, University of Sao Paulo, Sao ...
Frazão LB, Couto LA, Peres ACAM, Marques AP, Pássaro AC   +4 more
doaj  

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Unravelling social network usage patterns: A study based on unsupervised learning

Cyberpsychology: Journal of Psychosocial Research on Cyberpspace
We are facing a growing concern regarding the consequences of Problematic Social Network Use (PSNU). Therefore, the aim of the present study was to explore the profiles of social network (SN) users and contrast their differences across variables linked ...
Alfredo Zarco-Alpuente, Víctor Ciudad-Fernández, Marta Carrique-Martínez , Lucas Serrano-Pastor, Elisabeth Malonda-Vidal, Anna Llorca-Mestre , Rafael García-Ros, Paula Samper-García   +7 more
doaj   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

بررسي ساختار سازه ای واکه های زبان فارسی در دانش آموزان مبتلا به شکاف لب و کام در محدوده ی سنی 9-7 ساله

مجله پژوهش در علوم توانبخشی, 2011
چكيده مقدمه:اهميت فركانس سازه اي به گونه اي است كه روابط ميان سه سازه اول از اجزاي اصلي تشخيص نوع واكه توسط فرد شنونده مي باشد. به علاوه كيفيت يك واكه به بسامد سازه هاي آن بستگي دارد، بنابراين كاربرد اصلي اندازه گيري بسامد سازه در توصيف خطاهاي واكه اي ...
Faranak Salehi, Akbar Bahrami, Tahereh Karimi, Sonia Hasanpur, Ashrafosadat Musavi   +4 more
doaj   +1 more source